1-Hydroxymethyl-4-methoxy-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Base Information

• Chemical Name: 1-Hydroxymethyl-4-methoxy-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide
• CAS No.: 223677-08-5
• Molecular Formula: C₁₉H₂₈N₂O₄
• Molecular Weight: 348.442
• Mol file: 223677-08-5.mol

Synonyms:1-Hydroxymethyl-4-methoxy-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Chemical Property of 1-Hydroxymethyl-4-methoxy-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Hydroxymethyl-4-methoxy-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

There total 6 articles about 1-Hydroxymethyl-4-methoxy-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Benzyloxymethyl-4-methoxy-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide → 1-Hydroxymethyl-4-methoxy-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide (223677-08-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; under 3102.89 Torr;

DOI:10.1016/S0960-894X(98)00716-1

Reference yield:

Ethyl 4-hydroxybenzoate (120-47-8) → 1-Hydroxymethyl-4-methoxy-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide (223677-08-5)

Guidance literature:

Multi-step reaction with 6 steps

1: K₂CO₃

2: H₂ / 5 percent Rh/C / ethanol / 2585.74 Torr

3: LDA / 0 °C

4: KOH / ethanol / Heating

5: 1-hydroxy-7-azabenzotriazole, 1,3-dicyclohexylcarbodiimide, Et₃N / CH₂Cl₂

6: H₂, HCl / 10 percent Pd/C / ethanol / 3102.89 Torr

With hydrogenchloride; potassium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium on activated charcoal; Rh on carbon; In ethanol; dichloromethane;

DOI:10.1016/S0960-894X(98)00716-1

Reference yield:

ethyl 4-methoxybenzoate (94-30-4) → 1-Hydroxymethyl-4-methoxy-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide (223677-08-5)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / 5 percent Rh/C / ethanol / 2585.74 Torr

2: LDA / 0 °C

3: KOH / ethanol / Heating

4: 1-hydroxy-7-azabenzotriazole, 1,3-dicyclohexylcarbodiimide, Et₃N / CH₂Cl₂

5: H₂, HCl / 10 percent Pd/C / ethanol / 3102.89 Torr

With hydrogenchloride; potassium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; triethylamine; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium on activated charcoal; Rh on carbon; In ethanol; dichloromethane;

DOI:10.1016/S0960-894X(98)00716-1

upstream raw materials:

Ethyl 4-hydroxybenzoate

ethyl 4-methoxybenzoate

ethyl 4-methoxycyclohexanecarboxylate

cis-1-benzyloxymethyl-4-methoxycyclohexanecarboxylic acid