2,5-bis(5-(3-(4-aminophenoxy)phenyl)-1,3,4-oxadiazole-2-yl)benzene-1,4-diol

Base Information

• Chemical Name: 2,5-bis(5-(3-(4-aminophenoxy)phenyl)-1,3,4-oxadiazole-2-yl)benzene-1,4-diol
• CAS No.: 1253119-95-7
• Molecular Formula: C₃₄H₂₄N₆O₆
• Molecular Weight: 612.601
• Mol file: 1253119-95-7.mol

Synonyms:2,5-bis(5-(3-(4-aminophenoxy)phenyl)-1,3,4-oxadiazole-2-yl)benzene-1,4-diol

Chemical Property of 2,5-bis(5-(3-(4-aminophenoxy)phenyl)-1,3,4-oxadiazole-2-yl)benzene-1,4-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-bis(5-(3-(4-aminophenoxy)phenyl)-1,3,4-oxadiazole-2-yl)benzene-1,4-diol

There total 12 articles about 2,5-bis(5-(3-(4-aminophenoxy)phenyl)-1,3,4-oxadiazole-2-yl)benzene-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-bis(5-(3-(4-nitrophenoxy)phenyl)-1,3,4-oxadiazole-2-yl)benzene-1,4-diol (1253119-94-6) → 2,5-bis(5-(3-(4-aminophenoxy)phenyl)-1,3,4-oxadiazole-2-yl)benzene-1,4-diol (1253119-95-7)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In tetrahydrofuran; for 18h; under 1520.1 - 2280.15 Torr;

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 2,5-bis(5-(3-(4-aminophenoxy)phenyl)-1,3,4-oxadiazole-2-yl)benzene-1,4-diol (1253119-95-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium carbonate / dimethyl sulfoxide / 12 h / 130 °C

2.1: hydrogenchloride / water / 12 h / 110 °C

3.1: hydrazine hydrate / ethanol / 24 h / Reflux

4.1: tetrahydrofuran / 12 h / 20 °C

5.1: trichlorophosphate / 12 h / 90 °C

5.2: Cooling with ice

6.1: boron tribromide / dichloromethane / -78 - 0 °C

7.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 18 h / 1520.1 - 2280.15 Torr

With hydrogenchloride; hydrogen; boron tribromide; potassium carbonate; hydrazine hydrate; trichlorophosphate; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

2,5-bis(hexyloxy)terephthalic acid diethyl ester (149697-46-1) → 2,5-bis(5-(3-(4-aminophenoxy)phenyl)-1,3,4-oxadiazole-2-yl)benzene-1,4-diol (1253119-95-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium hydroxide / ethanol / 12 h / Reflux

1.2: pH 4

2.1: N,N-dimethyl-formamide; thionyl chloride / 6 h / 80 °C

3.1: tetrahydrofuran / 12 h / 20 °C

4.1: trichlorophosphate / 12 h / 90 °C

4.2: Cooling with ice

5.1: boron tribromide / dichloromethane / -78 - 0 °C

6.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 18 h / 1520.1 - 2280.15 Torr

With thionyl chloride; hydrogen; boron tribromide; N,N-dimethyl-formamide; potassium hydroxide; trichlorophosphate; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; dichloromethane;

upstream raw materials:

3-Carboxyphenol

4-Fluoronitrobenzene

3-(4-nitrophenoxy)benzoic acid

ethyl 3-(4'-nitrophenoxy)benzoate

Downstream raw materials:

2,5-bis(5-(3-(4-(2-(2-hydroxyphenyl)-4,5-diphenyl-1H-imidazole-1-yl)phenoxy)phenyl)-1,3,4-oxadiazole-2-yl)benzene-1,4-diol