Chemical Property of DEOXYCHOLIC-2,2,4,4-D4 ACID
Chemical Property:
- Melting Point:171-174 °C
- Flash Point:9℃
- PSA：77.76000
- LogP:4.47790
- Storage Temp.:-20°C
- Solubility.:DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
- Purity/Quality:
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99%, *data from raw suppliers
Deoxycholic acid-D4
100?μg/mL in methanol, certified reference material, Cerilliant?
*data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22-36/37/38
- Safety Statements:
26-36
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
Deoxycholic acid-d4 (DCA-d4) is intended for use as an internal standard for the quantification of DCA (Item Nos. 20756 | 18231) by GC- or LC-MS. DCA is a secondary bile acid that is formed via microbial transformation of cholic acid in the colon. It can be conjugated to glycine or taurine to produce glycodeoxycholic acid (GDCA; ) or taurodeoxycholic acid (TDCA; ), respectively, in hepatocytes. DCA (0.2% v/v) inhibits spore germination induced by taurocholic acid (TCA; ) in seven C. difficile strains, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.02% v/v. It inhibits ionizing radiation-induced p53-dependent transcription in a reporter assay using HCT116 cells when used at a concentration of 200 μM. Fecal and intestinal tissue levels of DCA are increased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet. Increased serum DCA levels have been found in patients with colorectal cancer.
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Uses
Deoxycholic-2,2,4,4-d4 Acid (CAS# 112076-61-6) is a useful isotopically labeled research compound.
