(S)-2-{[(S)-1-(2-{(S)-2-[(S)-2-(2-Amino-2-methyl-propionylamino)-3-carbamoyl-propionylamino]-4-methyl-pentanoylamino}-2-methyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-benzyloxy-propionic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-{[(S)-1-(2-{(S)-2-[(S)-2-(2-Amino-2-methyl-propionylamino)-3-carbamoyl-propionylamino]-4-methyl-pentanoylamino}-2-methyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-benzyloxy-propionic acid tert-butyl ester
CAS No.:913738-17-7
Molecular Formula:C₃₇H₅₉N₇O₉
Molecular Weight:745.917
Hs Code.:

(S)-2-{[(S)-1-(2-{(S)-2-[(S)-2-(2-Amino-2-methyl-propionylamino)-3-carbamoyl-propionylamino]-4-methyl-pentanoylamino}-2-methyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-benzyloxy-propionic acid tert-butyl ester

Synonyms:(S)-2-{[(S)-1-(2-{(S)-2-[(S)-2-(2-Amino-2-methyl-propionylamino)-3-carbamoyl-propionylamino]-4-methyl-pentanoylamino}-2-methyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-benzyloxy-propionic acid tert-butyl ester

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Chemical Property of (S)-2-{[(S)-1-(2-{(S)-2-[(S)-2-(2-Amino-2-methyl-propionylamino)-3-carbamoyl-propionylamino]-4-methyl-pentanoylamino}-2-methyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-benzyloxy-propionic acid tert-butyl ester

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Technology Process of (S)-2-{[(S)-1-(2-{(S)-2-[(S)-2-(2-Amino-2-methyl-propionylamino)-3-carbamoyl-propionylamino]-4-methyl-pentanoylamino}-2-methyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-benzyloxy-propionic acid tert-butyl ester

There total 1 articles about (S)-2-{[(S)-1-(2-{(S)-2-[(S)-2-(2-Amino-2-methyl-propionylamino)-3-carbamoyl-propionylamino]-4-methyl-pentanoylamino}-2-methyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-benzyloxy-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 916262-68-5
prop-2-enyl N-(2,2-dimethyl-2H-azirin-3-yl)-L-prolinate

: 2748-02-9,13081-32-8
L-leucine tert-butyl ester hydrochloride

: 63094-81-5
L-asparagine 1,1-dimethylethyl ester monohydrochloride

: (2S)-2-amino-3-benzyloxypropionic acid tert-butyl ester hydrochloride

: 913738-17-7
(S)-2-{[(S)-1-(2-{(S)-2-[(S)-2-(2-Amino-2-methyl-propionylamino)-3-carbamoyl-propionylamino]-4-methyl-pentanoylamino}-2-methyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-benzyloxy-propionic acid tert-butyl ester

Guidance literature:: Multistep reaction;
DOI:10.1016/j.tet.2006.07.082

Reference yield: 89.0%

: 913738-17-7
(S)-2-{[(S)-1-(2-{(S)-2-[(S)-2-(2-Amino-2-methyl-propionylamino)-3-carbamoyl-propionylamino]-4-methyl-pentanoylamino}-2-methyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-benzyloxy-propionic acid tert-butyl ester

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: (S)-3-Benzyloxy-2-{[(S)-1-(2-{(S)-2-[(S)-2-(2-benzyloxycarbonylamino-2-methyl-propionylamino)-3-carbamoyl-propionylamino]-4-methyl-pentanoylamino}-2-methyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-propionic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃; for 3h;
DOI:10.1016/j.tet.2006.07.082

Reference yield:

: 913738-17-7
(S)-2-{[(S)-1-(2-{(S)-2-[(S)-2-(2-Amino-2-methyl-propionylamino)-3-carbamoyl-propionylamino]-4-methyl-pentanoylamino}-2-methyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-benzyloxy-propionic acid tert-butyl ester

: 913738-20-2
(S)-3-Benzyloxy-2-{[(S)-1-(2-{(S)-2-[(S)-2-(2-benzyloxycarbonylamino-2-methyl-propionylamino)-3-carbamoyl-propionylamino]-4-methyl-pentanoylamino}-2-methyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / ethyldiisopropylamine / dioxane / 3 h / 20 °C

2: 8.9 mg / trifluoroacetic acid; triisopropylsilane / CH₂Cl₂ / 1 h / 20 °C

With chlorotriisopropylsilane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.tet.2006.07.082