4-METHOXY-D3-BENZALDEHYDE-ALPHA-D1

Base Information

• Chemical Name: 4-METHOXY-D3-BENZALDEHYDE-ALPHA-D1
• CAS No.: 342611-03-4
• Molecular Formula: C8H4 D4 O2
• Molecular Weight: 140.119
• Mol file: 342611-03-4.mol

Synonyms:

Chemical Property of 4-METHOXY-D3-BENZALDEHYDE-ALPHA-D1

Chemical Property:

• PSA: 26.30000
• LogP: 1.50770

Purity/Quality:

99% ^*data from raw suppliers

4-METHOXY-D3-BENZALDEHYDE-ALPHA-D1 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXY-D3-BENZALDEHYDE-ALPHA-D1

There total 3 articles about 4-METHOXY-D3-BENZALDEHYDE-ALPHA-D1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C8H5(2)H5O2 → C8H4(2)H4O2 (342611-03-4)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → C8H4(2)H4O2 (342611-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 0.5 h / 0 - 20 °C / Inert atmosphere

2.1: lithium aluminium deuteride / tetrahydrofuran / 1.5 h / 70 °C / Inert atmosphere

3.1: dipyridinium dichromate / dichloromethane / 24 h / 20 °C / Inert atmosphere

With dipyridinium dichromate; lithium aluminium deuteride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1039/c5cc09137c

Reference yield:

methyl 4-(methoxy-d3)benzoate (1126856-38-9) → C8H4(2)H4O2 (342611-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium deuteride / tetrahydrofuran / 1.5 h / 70 °C / Inert atmosphere

2: dipyridinium dichromate / dichloromethane / 24 h / 20 °C / Inert atmosphere

With dipyridinium dichromate; lithium aluminium deuteride; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c5cc09137c

upstream raw materials:

methyl 4-hydroxylbenzoate

methyl 4-(methoxy-d₃)benzoate

Refernces

• 1、 Tzirakis, Manolis D.,Orfanopoulos, Michael. "Acyl radical reactions in fullerene chemistry: Direct acylation of [60]fullerene through an efficient decatungstate-photomediated approach". supporting information; experimental part. p. 4063 - 4069. Retrieved 2009/09/05.