Technology Process of 3,6-anhydro-2-benzamido-4-O-benzoyl-2-deoxy-5,7,8-tri-O-methyl-D-erythro-L-ido-octitol
There total 11 articles about 3,6-anhydro-2-benzamido-4-O-benzoyl-2-deoxy-5,7,8-tri-O-methyl-D-erythro-L-ido-octitol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride; pyridine hydrochloride;
In
tetrahydrofuran;
for 12h;
DOI:10.1021/jo981435w
- Guidance literature:
-
Multi-step reaction with 10 steps
1: pyridine / 14 h
2: 85 percent / BF3*Et2O / CH2Cl2 / 1.5 h / 0 °C
3: 96 percent / K2CO3 / tetrahydrofuran; methanol / 0.25 h
4: DCC, DMAP / CH2Cl2 / 12 h
5: 42 percent / Bu3SnH, AIBN / toluene / Heating
6: LiAlH4 / tetrahydrofuran / 0 °C
7: imidazole / CH2Cl2 / 3.5 h
8: camphorsulfonic acid, H2 / Pd-C / ethyl acetate; methanol / 2 h / 2585.74 Torr
9: Et3N, DMAP / CH2Cl2 / 24 h
10: 83 percent / Bu4NF, pyridinium hydrochloride / tetrahydrofuran / 12 h
With
1H-imidazole; dmap; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); camphor-10-sulfonic acid; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; tri-n-butyl-tin hydride; pyridine hydrochloride; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; methanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jo981435w
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 85 percent / BF3*Et2O / CH2Cl2 / 1.5 h / 0 °C
2: 96 percent / K2CO3 / tetrahydrofuran; methanol / 0.25 h
3: DCC, DMAP / CH2Cl2 / 12 h
4: 42 percent / Bu3SnH, AIBN / toluene / Heating
5: LiAlH4 / tetrahydrofuran / 0 °C
6: imidazole / CH2Cl2 / 3.5 h
7: camphorsulfonic acid, H2 / Pd-C / ethyl acetate; methanol / 2 h / 2585.74 Torr
8: Et3N, DMAP / CH2Cl2 / 24 h
9: 83 percent / Bu4NF, pyridinium hydrochloride / tetrahydrofuran / 12 h
With
1H-imidazole; dmap; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); camphor-10-sulfonic acid; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; tri-n-butyl-tin hydride; pyridine hydrochloride; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jo981435w
