methyl 2-<(2-(methylamino)-5-oxo-1-cyclopenten-1-yl)methyl>benzoate

Base Information

• Chemical Name: methyl 2-<(2-(methylamino)-5-oxo-1-cyclopenten-1-yl)methyl>benzoate
• CAS No.: 75291-43-9
• Molecular Formula: C₁₅H₁₇NO₃
• Molecular Weight: 259.305
• Mol file: 75291-43-9.mol

Synonyms:methyl 2-<(2-(methylamino)-5-oxo-1-cyclopenten-1-yl)methyl>benzoate

Chemical Property of methyl 2-<(2-(methylamino)-5-oxo-1-cyclopenten-1-yl)methyl>benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 2-<(2-(methylamino)-5-oxo-1-cyclopenten-1-yl)methyl>benzoate

There total 2 articles about methyl 2-<(2-(methylamino)-5-oxo-1-cyclopenten-1-yl)methyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2,3,4,10-tetrahydro-4-methyl-benzocyclopentazepine-1,5-dione (75291-41-7) → methyl 2-<(2-(methylamino)-5-oxo-1-cyclopenten-1-yl)methyl>benzoate (75291-43-9)

Guidance literature:

With potassium carbonate; In methanol; for 0.25h; Ambient temperature;

DOI:10.1002/hlca.19800630421

Reference yield:

2,5-dihydro-2-methyl-1-oxo-1H-2-benzazepine-3-propanoic acid (75291-40-6) → methyl 2-<(2-(methylamino)-5-oxo-1-cyclopenten-1-yl)methyl>benzoate (75291-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / PPA / 0.75 h / 110 °C

2: 70 percent / 50percent aq. K₂CO₃ / methanol / 0.25 h / Ambient temperature

With potassium carbonate; In methanol;

DOI:10.1002/hlca.19800630421

Reference yield: 42.0%

methyl 2-<(2-(methylamino)-5-oxo-1-cyclopenten-1-yl)methyl>benzoate (75291-43-9) → 2-<(2-(hydroxymethyl)phenyl)methyl>-3-(methylamino)-2-cyclopenten-1-one (75291-44-0)

Guidance literature:

With sodium tetrahydroborate; In diethylene glycol dimethyl ether; 1) 80 deg C, 8 h, 2) 6 h, RT;

DOI:10.1002/hlca.19800630421

upstream raw materials:

2,3,4,10-tetrahydro-4-methyl-benzocyclopentazepine-1,5-dione

2,5-dihydro-2-methyl-1-oxo-1H-2-benzazepine-3-propanoic acid

Downstream raw materials:

2-<(2-(hydroxymethyl)phenyl)methyl>-3-(methylamino)-2-cyclopenten-1-one