methyl N-<2-((4-methoxyphenyl)-diphenylmethylamino)ethyl>-N-((thymin-1-yl)acetyl) glycinate

Base Information

• Chemical Name: methyl N-<2-((4-methoxyphenyl)-diphenylmethylamino)ethyl>-N-((thymin-1-yl)acetyl) glycinate
• CAS No.: 170944-06-6
• Molecular Formula: C₃₂H₃₄N₄O₆
• Molecular Weight: 570.645
• Mol file: 170944-06-6.mol

Synonyms:methyl N-<2-((4-methoxyphenyl)-diphenylmethylamino)ethyl>-N-((thymin-1-yl)acetyl) glycinate

Chemical Property of methyl N-<2-((4-methoxyphenyl)-diphenylmethylamino)ethyl>-N-((thymin-1-yl)acetyl) glycinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N-<2-((4-methoxyphenyl)-diphenylmethylamino)ethyl>-N-((thymin-1-yl)acetyl) glycinate

There total 6 articles about methyl N-<2-((4-methoxyphenyl)-diphenylmethylamino)ethyl>-N-((thymin-1-yl)acetyl) glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

thymidyl acetic acid (20924-05-4) + methyl N-<2-((4-methoxyphenyl)-diphenylmethyl)aminoethyl> glycinate (172405-21-9) → methyl N-<2-((4-methoxyphenyl)-diphenylmethylamino)ethyl>-N-((thymin-1-yl)acetyl) glycinate (170944-06-6)

Guidance literature:

With N-Ethylmaleimide; bis-2-propyl carbonate; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In N,N-dimethyl-formamide; for 20h; Ambient temperature;

DOI:10.1016/0040-4020(95)00766-2

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → methyl N-<2-((4-methoxyphenyl)-diphenylmethylamino)ethyl>-N-((thymin-1-yl)acetyl) glycinate (170944-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / DBU / CH₂Cl₂ / 0.67 h

2: DIEA / acetonitrile / 0.33 h

3: DCC / acetonitrile

With 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;

Reference yield:

N-(2-aminoethyl)glycine methyl ester dihydrochloride → methyl N-<2-((4-methoxyphenyl)-diphenylmethylamino)ethyl>-N-((thymin-1-yl)acetyl) glycinate (170944-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / NEt₃ / dimethylformamide; CH₂Cl₂ / 2.5 h / Ambient temperature

2: 91 percent / HOOBt, NEM, DIPC / dimethylformamide / 20 h / Ambient temperature

With N-Ethylmaleimide; bis-2-propyl carbonate; triethylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0040-4020(95)00766-2

upstream raw materials:

{(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester

mono-4-methoxytrityl chloride

thymidyl acetic acid

methyl N-<2-((4-methoxyphenyl)-diphenylmethyl)aminoethyl> glycinate

Downstream raw materials:

{(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid