4,4-dimethyl-5-nitro-6-[5-(2-p-tolyl-benzo[1,3]oxathiol-2-yl)-1H-pyrrol-2-yl]-hexan-2-one

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Chemical Name:4,4-dimethyl-5-nitro-6-[5-(2-p-tolyl-benzo[1,3]oxathiol-2-yl)-1H-pyrrol-2-yl]-hexan-2-one
CAS No.:276239-58-8
Molecular Formula:C₂₆H₂₈N₂O₄S
Molecular Weight:464.585
Hs Code.:

4,4-dimethyl-5-nitro-6-[5-(2-<i>p</i>-tolyl-benzo[1,3]oxathiol-2-yl)-1<i>H</i>-pyrrol-2-yl]-hexan-2-one

Synonyms:4,4-dimethyl-5-nitro-6-[5-(2-p-tolyl-benzo[1,3]oxathiol-2-yl)-1H-pyrrol-2-yl]-hexan-2-one

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Chemical Property of 4,4-dimethyl-5-nitro-6-[5-(2-p-tolyl-benzo[1,3]oxathiol-2-yl)-1H-pyrrol-2-yl]-hexan-2-one

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Technology Process of 4,4-dimethyl-5-nitro-6-[5-(2-p-tolyl-benzo[1,3]oxathiol-2-yl)-1H-pyrrol-2-yl]-hexan-2-one

There total 4 articles about 4,4-dimethyl-5-nitro-6-[5-(2-p-tolyl-benzo[1,3]oxathiol-2-yl)-1H-pyrrol-2-yl]-hexan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 2-(p-tolyl)-1,3-benzoxathiolium tetrafluoroborate

: 276239-27-1
4,4-dimethyl-5-nitro-6-(1H-pyrrol-2-yl)hexan-2-one

: 276239-58-8
4,4-dimethyl-5-nitro-6-[5-(2-p-tolyl-benzo[1,3]oxathiol-2-yl)-1H-pyrrol-2-yl]-hexan-2-one

Guidance literature:: With pyridine; In acetonitrile; for 1h;
DOI:10.1021/jo991942t

Reference yield:

: 1003-29-8,254729-95-8
2-pyrrole aldehyde

: 276239-58-8
4,4-dimethyl-5-nitro-6-[5-(2-p-tolyl-benzo[1,3]oxathiol-2-yl)-1H-pyrrol-2-yl]-hexan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / NaOAc; MeNH₂*HCl / methanol / 12 h / 20 °C

2: 60 percent / NaBH₄ / tetrahydrofuran; methanol / 2 h / 20 °C

3: 65 percent / CsF / acetonitrile / 16 h / 70 °C

4: 56 percent / pyridine / acetonitrile / 1 h

With pyridine; sodium tetrahydroborate; methylamine hydrochloride; sodium acetate; cesium fluoride; In tetrahydrofuran; methanol; acetonitrile; 1: Condensation / 2: Reduction / 3: Addition / 4: Addition;
DOI:10.1021/jo991942t

Reference yield:

: 276239-25-9
2-[(E)-2-nitroeth-1-enyl]-1H-pyrrole

: 276239-58-8
4,4-dimethyl-5-nitro-6-[5-(2-p-tolyl-benzo[1,3]oxathiol-2-yl)-1H-pyrrol-2-yl]-hexan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / NaBH₄ / tetrahydrofuran; methanol / 2 h / 20 °C

2: 65 percent / CsF / acetonitrile / 16 h / 70 °C

3: 56 percent / pyridine / acetonitrile / 1 h

With pyridine; sodium tetrahydroborate; cesium fluoride; In tetrahydrofuran; methanol; acetonitrile; 1: Reduction / 2: Addition / 3: Addition;
DOI:10.1021/jo991942t