2-(((2-(4-((tert-butoxycarbonyl)amino)phenyl)-3-(methoxycarbonyl)-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinolin-7-yl)oxy)methyl)pyridine 1-oxide

Base Information

Chemical Name:2-(((2-(4-((tert-butoxycarbonyl)amino)phenyl)-3-(methoxycarbonyl)-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinolin-7-yl)oxy)methyl)pyridine 1-oxide
CAS No.:212499-39-3
Molecular Formula:C₃₇H₃₇N₃O₁₀
Molecular Weight:683.715
Hs Code.:

2-(((2-(4-((tert-butoxycarbonyl)amino)phenyl)-3-(methoxycarbonyl)-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinolin-7-yl)oxy)methyl)pyridine 1-oxide

Synonyms:2-(((2-(4-((tert-butoxycarbonyl)amino)phenyl)-3-(methoxycarbonyl)-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinolin-7-yl)oxy)methyl)pyridine 1-oxide

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Chemical Property of 2-(((2-(4-((tert-butoxycarbonyl)amino)phenyl)-3-(methoxycarbonyl)-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinolin-7-yl)oxy)methyl)pyridine 1-oxide

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Technology Process of 2-(((2-(4-((tert-butoxycarbonyl)amino)phenyl)-3-(methoxycarbonyl)-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinolin-7-yl)oxy)methyl)pyridine 1-oxide

There total 4 articles about 2-(((2-(4-((tert-butoxycarbonyl)amino)phenyl)-3-(methoxycarbonyl)-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinolin-7-yl)oxy)methyl)pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 212498-35-6
methyl 2-(4-((t-butoxycarbonyl)amino)phenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinoline-3-carboxylate

: 212499-39-3
2-(((2-(4-((tert-butoxycarbonyl)amino)phenyl)-3-(methoxycarbonyl)-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinolin-7-yl)oxy)methyl)pyridine 1-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1124/dmd.113.054726

Reference yield:

: 347423-83-0
7-benzyloxy-2-[(4-tert-butoxycarbonylamino)phenyl]-1,2-dihydro-1-oxo-4-(3,4,5-trimethoxyphenyl)-3-isoquinolinecarboxylic acid

: 212499-39-3
2-(((2-(4-((tert-butoxycarbonyl)amino)phenyl)-3-(methoxycarbonyl)-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinolin-7-yl)oxy)methyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / Inert atmosphere

2: palladium on activated charcoal; hydrogen / Inert atmosphere

3: potassium carbonate / Inert atmosphere

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1124/dmd.113.054726

Reference yield:

: 212492-68-7
methyl 7-benzyloxy-2-[(4-tert-butoxycarbonylamino)phenyl]-1,2-dihydro-1-oxo-4-(3,4,5-trimethoxyphenyl)-3-isoquinolinecarboxylate

: 212499-39-3
2-(((2-(4-((tert-butoxycarbonyl)amino)phenyl)-3-(methoxycarbonyl)-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinolin-7-yl)oxy)methyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / Inert atmosphere

2: potassium carbonate / Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1124/dmd.113.054726