(R)-1-benzyl-3-((tetrahydro-2H-pyran-2-yloxy)methyl)piperazine-2,5-dione

Base Information

Chemical Name:(R)-1-benzyl-3-((tetrahydro-2H-pyran-2-yloxy)methyl)piperazine-2,5-dione
CAS No.:1060720-31-1
Molecular Formula:C₁₇H₂₂N₂O₄
Molecular Weight:318.373
Hs Code.:

Synonyms:(R)-1-benzyl-3-((tetrahydro-2H-pyran-2-yloxy)methyl)piperazine-2,5-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-benzyl-3-((tetrahydro-2H-pyran-2-yloxy)methyl)piperazine-2,5-dione

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Technology Process of (R)-1-benzyl-3-((tetrahydro-2H-pyran-2-yloxy)methyl)piperazine-2,5-dione

There total 1 articles about (R)-1-benzyl-3-((tetrahydro-2H-pyran-2-yloxy)methyl)piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 149648-95-3
(R)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione

: 1060720-31-1
(R)-1-benzyl-3-((tetrahydro-2H-pyran-2-yloxy)methyl)piperazine-2,5-dione

Guidance literature:: 3,4-dihydro-2H-pyran; (R)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione; With toluene-4-sulfonic acid; In dichloromethane; at 0 ℃; for 0.5h;

With water; sodium hydrogencarbonate; In dichloromethane; Saturated solution;

Reference yield: 99.0%

: 1060720-31-1
(R)-1-benzyl-3-((tetrahydro-2H-pyran-2-yloxy)methyl)piperazine-2,5-dione

: 1060720-33-3
(S)-1-benzyl-3-[(tetrahydro-2H-pyran-2-yloxy)methyl]piperazine

Guidance literature:: (R)-1-benzyl-3-((tetrahydro-2H-pyran-2-yloxy)methyl)piperazine-2,5-dione; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 3h; Heating / reflux;

With sodium hydroxide; water; In tetrahydrofuran;

Reference yield:

: 1060720-31-1
(R)-1-benzyl-3-((tetrahydro-2H-pyran-2-yloxy)methyl)piperazine-2,5-dione

: 1060720-34-4
(S)-1-[4'-benzyl-(2'-hydroxymethyl)piperazin-1'-yl]isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Heating / reflux

2.1: n-butyllithium / diethyl ether / 0.25 h / 0 °C

2.2: 14 h / 20 °C

3.1: hydrogenchloride; methanol; water / 3 h / 20 °C

3.2: Saturated solution

With hydrogenchloride; methanol; lithium aluminium tetrahydride; n-butyllithium; water; In tetrahydrofuran; diethyl ether;