N-<(1,1-dimethylethoxy)carbonyl>-4(R)-(4-chlorophenoxy)-(S)-proline

Base Information

• Chemical Name: N-<(1,1-dimethylethoxy)carbonyl>-4(R)-(4-chlorophenoxy)-(S)-proline
• CAS No.: 113507-43-0
• Molecular Formula: C₁₆H₂₀ClNO₅
• Molecular Weight: 341.791
• Mol file: 113507-43-0.mol

Synonyms:N-<(1,1-dimethylethoxy)carbonyl>-4(R)-(4-chlorophenoxy)-(S)-proline

Chemical Property of N-<(1,1-dimethylethoxy)carbonyl>-4(R)-(4-chlorophenoxy)-(S)-proline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<(1,1-dimethylethoxy)carbonyl>-4(R)-(4-chlorophenoxy)-(S)-proline

There total 1 articles about N-<(1,1-dimethylethoxy)carbonyl>-4(R)-(4-chlorophenoxy)-(S)-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Chloro-4-fluorobenzene (352-33-0) + (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid (13726-69-7,946610-68-0) → N-<(1,1-dimethylethoxy)carbonyl>-4(R)-(4-chlorophenoxy)-(S)-proline (113507-43-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 95 ℃; for 18h;

DOI:10.1021/jm00399a033

Reference yield:

N-<(1,1-dimethylethoxy)carbonyl>-4(R)-(4-chlorophenoxy)-(S)-proline (113507-43-0) → (2S,4R)-4-(4-Chloro-phenoxy)-1-(3-mercapto-2-methyl-propionyl)-pyrrolidine-2-carboxylic acid

Guidance literature:

Multi-step reaction with 3 steps

1: 0.04 g / SOCl₂ / 18 h / Ambient temperature

2: 68 percent / pyridine / 18 h / Ambient temperature

3: 72 percent

With thionyl chloride; In pyridine;

DOI:10.1021/jm00399a033

Reference yield:

N-<(1,1-dimethylethoxy)carbonyl>-4(R)-(4-chlorophenoxy)-(S)-proline (113507-43-0) → (2S,4R)-1-(3-Acetylsulfanyl-2-methyl-propionyl)-4-(4-chloro-phenoxy)-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 0.04 g / SOCl₂ / 18 h / Ambient temperature

2: 68 percent / pyridine / 18 h / Ambient temperature

With thionyl chloride; In pyridine;

DOI:10.1021/jm00399a033

upstream raw materials:

1-Chloro-4-fluorobenzene

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid