N-de-tert-butoxycarbonyl-N-[2-(1,1-difluoro-2-methyl)propyloxycarbonyl]-7,10-di-(2,2,2-trichloroethyloxycarbonyl)-3-dephenyl-3'-(4-fluorophenyl)docetaxel

Base Information

Chemical Name:N-de-tert-butoxycarbonyl-N-[2-(1,1-difluoro-2-methyl)propyloxycarbonyl]-7,10-di-(2,2,2-trichloroethyloxycarbonyl)-3-dephenyl-3'-(4-fluorophenyl)docetaxel
CAS No.:1300036-12-7
Molecular Formula:C₄₉H₅₂Cl₆F₃NO₁₈
Molecular Weight:1212.66
Hs Code.:

N-de-tert-butoxycarbonyl-N-[2-(1,1-difluoro-2-methyl)propyloxycarbonyl]-7,10-di-(2,2,2-trichloroethyloxycarbonyl)-3-dephenyl-3'-(4-fluorophenyl)docetaxel

Synonyms:N-de-tert-butoxycarbonyl-N-[2-(1,1-difluoro-2-methyl)propyloxycarbonyl]-7,10-di-(2,2,2-trichloroethyloxycarbonyl)-3-dephenyl-3'-(4-fluorophenyl)docetaxel

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Chemical Property of N-de-tert-butoxycarbonyl-N-[2-(1,1-difluoro-2-methyl)propyloxycarbonyl]-7,10-di-(2,2,2-trichloroethyloxycarbonyl)-3-dephenyl-3'-(4-fluorophenyl)docetaxel

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Technology Process of N-de-tert-butoxycarbonyl-N-[2-(1,1-difluoro-2-methyl)propyloxycarbonyl]-7,10-di-(2,2,2-trichloroethyloxycarbonyl)-3-dephenyl-3'-(4-fluorophenyl)docetaxel

There total 14 articles about N-de-tert-butoxycarbonyl-N-[2-(1,1-difluoro-2-methyl)propyloxycarbonyl]-7,10-di-(2,2,2-trichloroethyloxycarbonyl)-3-dephenyl-3'-(4-fluorophenyl)docetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.1%

: 912272-01-6
C₅H₇ClF₂O₂

: C₄₄H₄₆Cl₆FNO₁₆

: 1300036-12-7
N-de-tert-butoxycarbonyl-N-[2-(1,1-difluoro-2-methyl)propyloxycarbonyl]-7,10-di-(2,2,2-trichloroethyloxycarbonyl)-3-dephenyl-3'-(4-fluorophenyl)docetaxel

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2011.02.027

Reference yield:

: 1300036-09-2
isopropyl (2R,3S)-3-acetylamino-2-hydroxy-3-(4-fluorophenyl)propionate

: 1300036-12-7
N-de-tert-butoxycarbonyl-N-[2-(1,1-difluoro-2-methyl)propyloxycarbonyl]-7,10-di-(2,2,2-trichloroethyloxycarbonyl)-3-dephenyl-3'-(4-fluorophenyl)docetaxel

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogenchloride; water / 4 h / Reflux

2: thionyl chloride / 0 - 20 °C

3: triethylamine / dichloromethane / 48 h / 0 - 20 °C

4: pyridinium p-toluenesulfonate / toluene / 3 h / 90 °C

5: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 20 °C

6: dmap; dicyclohexyl-carbodiimide / toluene

7: formic acid / 2 h / 20 °C

8: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C

With hydrogenchloride; dmap; formic acid; thionyl chloride; water; pyridinium p-toluenesulfonate; triethylamine; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1016/j.ejmech.2011.02.027

Reference yield:

: 1300036-08-1
C₁₂H₁₃FO₂

: 1300036-12-7
N-de-tert-butoxycarbonyl-N-[2-(1,1-difluoro-2-methyl)propyloxycarbonyl]-7,10-di-(2,2,2-trichloroethyloxycarbonyl)-3-dephenyl-3'-(4-fluorophenyl)docetaxel

Guidance literature:: Multi-step reaction with 9 steps

1: potassium osmate(VI) dihydrate; lithium hydroxide monohydrate; hydroquinidein 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 10 h / 0 °C

2: hydrogenchloride; water / 4 h / Reflux

3: thionyl chloride / 0 - 20 °C

4: triethylamine / dichloromethane / 48 h / 0 - 20 °C

5: pyridinium p-toluenesulfonate / toluene / 3 h / 90 °C

6: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 20 °C

7: dmap; dicyclohexyl-carbodiimide / toluene

8: formic acid / 2 h / 20 °C

9: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C

With hydrogenchloride; dmap; potassium osmate(VI) dihydrate; formic acid; thionyl chloride; lithium hydroxide monohydrate; water; pyridinium p-toluenesulfonate; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; tert-butyl alcohol; 1: Sharpless aminohydroxylation;
DOI:10.1016/j.ejmech.2011.02.027