tert-Butyl 4-amino>-3-methoxybenzoate

Base Information

Chemical Name:tert-Butyl 4-amino>-3-methoxybenzoate
CAS No.:123330-93-8
Molecular Formula:C₁₈H₂₅NO₇
Molecular Weight:367.399
Hs Code.:

tert-Butyl 4-<bis<(methoxycarbonyl)methyl>amino>-3-methoxybenzoate

Synonyms:tert-Butyl 4-amino>-3-methoxybenzoate

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Chemical Property of tert-Butyl 4-amino>-3-methoxybenzoate

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Technology Process of tert-Butyl 4-amino>-3-methoxybenzoate

There total 4 articles about tert-Butyl 4-amino>-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 123330-92-7
4-amino-3-methoxybenzoic acid tert-butyl ester

: 96-32-2
bromoacetic acid methyl ester

: 123330-93-8
tert-Butyl 4-amino>-3-methoxybenzoate

Guidance literature:: With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; at 125 ℃; for 96h;
DOI:10.1021/ja00202a042

Reference yield:

: 5081-36-7
3-methoxy-4-nitrobenzoic acid

: 123330-93-8
tert-Butyl 4-amino>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 1 h / Heating

2: pyridine / CHCl₃ / 2 h / Heating

3: 65 percent / H₂ / 5percent Pd/C / ethyl acetate; ethanol / 5 h / Ambient temperature

4: 47 percent / 1,8-bis(dimethylamino)naphthalene / 96 h / 125 °C

With pyridine; thionyl chloride; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; palladium on activated charcoal; In ethanol; chloroform; ethyl acetate;
DOI:10.1021/ja00202a042

Reference yield:

: 5081-37-8
methyl 3-methoxy-4-nitrobenzoate

: 123330-93-8
tert-Butyl 4-amino>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: aq. 1M NaOH / methanol / 0.5 h

2: thionyl chloride / 1 h / Heating

3: pyridine / CHCl₃ / 2 h / Heating

4: 65 percent / H₂ / 5percent Pd/C / ethyl acetate; ethanol / 5 h / Ambient temperature

5: 47 percent / 1,8-bis(dimethylamino)naphthalene / 96 h / 125 °C

With pyridine; sodium hydroxide; thionyl chloride; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; palladium on activated charcoal; In methanol; ethanol; chloroform; ethyl acetate;
DOI:10.1021/ja00202a042