2-debenzoyl-2-(3-methoxybenzoyl)-10-deacetyl-10-propanoyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-docetaxel

Base Information

Chemical Name:2-debenzoyl-2-(3-methoxybenzoyl)-10-deacetyl-10-propanoyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-docetaxel
CAS No.:259522-52-6
Molecular Formula:C₄₅H₆₁NO₁₆
Molecular Weight:871.976
Hs Code.:

Synonyms:2-debenzoyl-2-(3-methoxybenzoyl)-10-deacetyl-10-propanoyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-docetaxel

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Chemical Property of 2-debenzoyl-2-(3-methoxybenzoyl)-10-deacetyl-10-propanoyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-docetaxel

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Technology Process of 2-debenzoyl-2-(3-methoxybenzoyl)-10-deacetyl-10-propanoyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-docetaxel

There total 8 articles about 2-debenzoyl-2-(3-methoxybenzoyl)-10-deacetyl-10-propanoyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-docetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₆₀H₉₅NO₁₆Si₂

: 259522-52-6
2-debenzoyl-2-(3-methoxybenzoyl)-10-deacetyl-10-propanoyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-docetaxel

Guidance literature:: With pyridine; hydrogen fluoride; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/S0960-894X(99)00629-0

Reference yield:

: 32981-86-5,172018-16-5
10-deacetylbaccatin III

: 259522-52-6
2-debenzoyl-2-(3-methoxybenzoyl)-10-deacetyl-10-propanoyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-docetaxel

Guidance literature:: Multi-step reaction with 8 steps

1: 96 percent / imidazole / dimethylformamide / 40 h / 20 °C

2: 97 percent / Red-Al / tetrahydrofuran / -10 °C

3: DIC; DMAP / CH₂Cl₂

4: HF*pyridine; pyridine / acetonitrile / 40 h / 20 °C

5: imidazole / dimethylformamide / 2 h / 20 °C

6: LiHMDS / tetrahydrofuran

7: LiHMDS / tetrahydrofuran / 0.5 h / -40 °C

8: HF/pyridine; pyridine / acetonitrile / 0 - 20 °C

With pyridine; 1H-imidazole; dmap; hydrogen fluoride; pyridine hydrogenfluoride; dacarbazine; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: silylation / 2: debenzoylation / 3: Esterification / 4: desilylation / 5: silylation / 6: Acylation / 7: Acylation / 8: desilylation;
DOI:10.1016/S0960-894X(99)00629-0

Reference yield:

: 194720-19-9
7,10,13-tris(triethylsilyl)-10-deacetylbaccatin III

: 259522-52-6
2-debenzoyl-2-(3-methoxybenzoyl)-10-deacetyl-10-propanoyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-docetaxel

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / Red-Al / tetrahydrofuran / -10 °C

2: DIC; DMAP / CH₂Cl₂

3: HF*pyridine; pyridine / acetonitrile / 40 h / 20 °C

4: imidazole / dimethylformamide / 2 h / 20 °C

5: LiHMDS / tetrahydrofuran

6: LiHMDS / tetrahydrofuran / 0.5 h / -40 °C

7: HF/pyridine; pyridine / acetonitrile / 0 - 20 °C

With pyridine; 1H-imidazole; dmap; hydrogen fluoride; pyridine hydrogenfluoride; dacarbazine; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: debenzoylation / 2: Esterification / 3: desilylation / 4: silylation / 5: Acylation / 6: Acylation / 7: desilylation;
DOI:10.1016/S0960-894X(99)00629-0