Technology Process of (7E,9E,11E)-16-benzyloxyhexadeca-7,9,11-trien-6-ol
There total 6 articles about (7E,9E,11E)-16-benzyloxyhexadeca-7,9,11-trien-6-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
silver(I) acetate; palladium diacetate;
In
N,N-dimethyl-formamide;
at 45 ℃;
for 17h;
stereoselective reaction;
DOI:10.1021/ol302719e
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: zirconocene dichloride; diisobutylaluminium hydride / tetrahydrofuran; hexane / 2 h / 0 - 20 °C
1.2: 0.5 h / -78 °C
2.1: silver(I) acetate; tris-(o-tolyl)phosphine; palladium diacetate / N,N-dimethyl-formamide; acetonitrile / 60 h / 50 °C
3.1: sodium methylate / tetrahydrofuran; methanol / 0.5 h / -78 °C
3.2: 1 h / -78 °C
4.1: silver(I) acetate; palladium diacetate / N,N-dimethyl-formamide / 17 h / 45 °C
With
zirconocene dichloride; sodium methylate; silver(I) acetate; palladium diacetate; diisobutylaluminium hydride; tris-(o-tolyl)phosphine;
In
tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetonitrile;
2.1: |Heck Reaction / 4.1: |Heck Reaction;
DOI:10.1021/ol302719e
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C
1.2: 17 h / 20 °C
2.1: zirconocene dichloride; diisobutylaluminium hydride / tetrahydrofuran; hexane / 2 h / 0 - 20 °C
2.2: 0.5 h / -78 °C
3.1: silver(I) acetate; tris-(o-tolyl)phosphine; palladium diacetate / N,N-dimethyl-formamide; acetonitrile / 60 h / 50 °C
4.1: sodium methylate / tetrahydrofuran; methanol / 0.5 h / -78 °C
4.2: 1 h / -78 °C
5.1: silver(I) acetate; palladium diacetate / N,N-dimethyl-formamide / 17 h / 45 °C
With
zirconocene dichloride; sodium methylate; silver(I) acetate; palladium diacetate; sodium hydride; diisobutylaluminium hydride; tris-(o-tolyl)phosphine;
In
tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetonitrile;
3.1: |Heck Reaction / 5.1: |Heck Reaction;
DOI:10.1021/ol302719e
