6-(trifluoromethyl)-1-(4-iodophenyl)-3-(4-(hydroxycarbonyl)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

Base Information

Chemical Name:6-(trifluoromethyl)-1-(4-iodophenyl)-3-(4-(hydroxycarbonyl)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl
CAS No.:1621378-29-7
Molecular Formula:C₂₁H₁₂F₃IN₃O₂
Molecular Weight:522.245
Hs Code.:

Synonyms:6-(trifluoromethyl)-1-(4-iodophenyl)-3-(4-(hydroxycarbonyl)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

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Chemical Property of 6-(trifluoromethyl)-1-(4-iodophenyl)-3-(4-(hydroxycarbonyl)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

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Technology Process of 6-(trifluoromethyl)-1-(4-iodophenyl)-3-(4-(hydroxycarbonyl)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

There total 9 articles about 6-(trifluoromethyl)-1-(4-iodophenyl)-3-(4-(hydroxycarbonyl)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1621377-82-9
6-(trifluoromethyl)-1-(4-iodophenyl)-3-(4-(methoxycarbonyl)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

: 1621378-29-7
6-(trifluoromethyl)-1-(4-iodophenyl)-3-(4-(hydroxycarbonyl)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; ethanol; water; at 60 ℃; for 48h; regiospecific reaction; Inert atmosphere;
DOI:10.1021/jo500898e

Reference yield:

: 1621378-11-7
C₂₂H₁₅F₃IN₃O₂

: 1621378-29-7
6-(trifluoromethyl)-1-(4-iodophenyl)-3-(4-(hydroxycarbonyl)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

Guidance literature:: Multi-step reaction with 2 steps

1: sodium periodate / dichloromethane; water; methanol / 0.05 h / 20 °C / Inert atmosphere

2: potassium hydroxide / water; tetrahydrofuran; ethanol / 48 h / 60 °C / Inert atmosphere

With sodium periodate; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1021/jo500898e

Reference yield:

: 367-86-2
1-fluoro-2-nitro-4-trifluoromethyl-benzene

: 1621378-29-7
6-(trifluoromethyl)-1-(4-iodophenyl)-3-(4-(hydroxycarbonyl)phenyl)-1,2-dihydrobenzo[1,2,4]triazin-2-yl

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / water; dimethyl sulfoxide / 20 °C / Inert atmosphere

2: hydroxylamine hydrochloride / pyridine / 20 h / 80 °C / Inert atmosphere

3: triethylamine / dichloromethane / -5 - 20 °C / Inert atmosphere

4: tin / acetic acid / 0.67 h / 20 - 118 °C / Inert atmosphere

5: sodium periodate / dichloromethane; water; methanol / 0.05 h / 20 °C / Inert atmosphere

6: potassium hydroxide / water; tetrahydrofuran; ethanol / 48 h / 60 °C / Inert atmosphere

With tin; sodium periodate; hydroxylamine hydrochloride; potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; water; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jo500898e