1-(5-(5-chloro-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

Base Information

Chemical Name:1-(5-(5-chloro-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol
CAS No.:1350376-76-9
Molecular Formula:C₃₀H₂₇ClN₄O₃S₂
Molecular Weight:591.154
Hs Code.:

Synonyms:1-(5-(5-chloro-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

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Chemical Property of 1-(5-(5-chloro-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

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Technology Process of 1-(5-(5-chloro-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

There total 9 articles about 1-(5-(5-chloro-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350376-74-7
tert-butyl 7-(5-chloro-4-(2-(1-(methoxymethoxy)cyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1350376-76-9
1-(5-(5-chloro-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

Guidance literature:: With hydrogenchloride; In methanol; water; at 65 ℃; for 3h;

Reference yield:

: 1350375-66-4
5-(5-chloro-2-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-(1-(methoxymethoxy)cyclobutyl)thiazole

: 1350376-76-9
1-(5-(5-chloro-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4 h / 65 °C

2: hydrogenchloride / water; methanol / 3 h / 65 °C

With hydrogenchloride; sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1350375-65-3
5-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-(1-(methoxymethoxy)cyclobutyl)thiazole

: 1350376-76-9
1-(5-(5-chloro-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

1.2: 0.25 h

2.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4 h / 65 °C

3.1: hydrogenchloride / water; methanol / 3 h / 65 °C

With hydrogenchloride; sodium hydrogencarbonate; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;