Technology Process of methyl 2-(4-bromo-2-nitrophenyl)-4-methylmorpholine-2-carboxylate
There total 4 articles about methyl 2-(4-bromo-2-nitrophenyl)-4-methylmorpholine-2-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 2-(4-bromo-2-nitrophenyl)-2-hydroxy-3-((2-hydroxyethyl)(methyl)amino)propanoate;
With
Tris(3,6-dioxaheptyl)amine; potassium hydroxide;
In
1,4-dioxane;
at 50 ℃;
for 27h;
With
p-toluenesulfonyl chloride;
In
1,4-dioxane;
at 20 ℃;
for 4.05h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Cooling with ice
1.2: Cooling with ice
2.1: potassium carbonate / water / 6 h / 60 °C
3.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 48 h / Reflux
4.1: tetrahydrofuran / 27 h / 50 °C
5.1: Tris(3,6-dioxaheptyl)amine; potassium hydroxide / 1,4-dioxane / 27 h / 50 °C
5.2: 4.05 h / 20 °C
With
Tris(3,6-dioxaheptyl)amine; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 48 h / Reflux
2.1: tetrahydrofuran / 27 h / 50 °C
3.1: Tris(3,6-dioxaheptyl)amine; potassium hydroxide / 1,4-dioxane / 27 h / 50 °C
3.2: 4.05 h / 20 °C
With
Tris(3,6-dioxaheptyl)amine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; chloroform;
