2-methyl-azetidine-1,2-dicarboxylic acid-1-[(4-bromo-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate

Base Information

Chemical Name:2-methyl-azetidine-1,2-dicarboxylic acid-1-[(4-bromo-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate
CAS No.:1080645-31-3
Molecular Formula:C₂HF₃O₂*C₂₂H₂₅BrN₄O₂
Molecular Weight:571.394
Hs Code.:

Synonyms:2-methyl-azetidine-1,2-dicarboxylic acid-1-[(4-bromo-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate

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Chemical Property of 2-methyl-azetidine-1,2-dicarboxylic acid-1-[(4-bromo-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate

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Technology Process of 2-methyl-azetidine-1,2-dicarboxylic acid-1-[(4-bromo-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate

There total 6 articles about 2-methyl-azetidine-1,2-dicarboxylic acid-1-[(4-bromo-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-methyl-azetidine-2-carboxylic acid-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide bis-trifluoroacetate

: 2493-02-9
4-bromophenyl isocyanate

: 76-05-1
trifluoroacetic acid

: 1080645-31-3
2-methyl-azetidine-1,2-dicarboxylic acid-1-[(4-bromo-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate

Guidance literature:: 2-methyl-azetidine-2-carboxylic acid-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide bis-trifluoroacetate; 4-bromophenyl isocyanate; With triethylamine; In N,N-dimethyl-formamide;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 14097-37-1
2-methyl-1,2,3,4-tetrahydroisoquinolin-6-amine

: 1080645-31-3
2-methyl-azetidine-1,2-dicarboxylic acid-1-[(4-bromo-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.25 h

1.2: 3 h / 20 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 4.5 h / 20 °C / 2250.23 Torr

3.1: triethylamine / N,N-dimethyl-formamide

With 4-methyl-morpholine; hydrogen; triethylamine; HATU; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

Reference yield:

: C₁₂H₁₅NO₂

: 1080645-31-3
2-methyl-azetidine-1,2-dicarboxylic acid-1-[(4-bromo-phenyl)-amide]-2-[(2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide] trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.25 h

1.2: 3 h / 20 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 4.5 h / 20 °C / 2250.23 Torr

3.1: triethylamine / N,N-dimethyl-formamide

With 4-methyl-morpholine; hydrogen; triethylamine; HATU; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;