3-4-(4-Chlorphenyl)-(4-hydroxy-3-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

Base Information

Chemical Name:3-4-(4-Chlorphenyl)-(4-hydroxy-3-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure
CAS No.:122504-63-6
Molecular Formula:C₂₆H₂₇ClN₂O₄
Molecular Weight:466.964
Hs Code.:

Synonyms:3-4-(4-Chlorphenyl)-(4-hydroxy-3-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

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Chemical Property of 3-4-(4-Chlorphenyl)-(4-hydroxy-3-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

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Technology Process of 3-4-(4-Chlorphenyl)-(4-hydroxy-3-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

There total 4 articles about 3-4-(4-Chlorphenyl)-(4-hydroxy-3-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 122504-62-5
3-4-(4-Chlorphenyl)-(4-benzyloxy-3-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

: 122504-63-6
3-4-(4-Chlorphenyl)-(4-hydroxy-3-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; for 22h; Ambient temperature;
DOI:10.1002/ardp.19893220606

Reference yield:

: 106-39-8
bromochlorobenzene

: 122504-63-6
3-4-(4-Chlorphenyl)-(4-hydroxy-3-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Mg / 1.) ether, 2.) reflux, 2 h

2: SOCl₂ / 1.) overnight, 2.) reflux, 1 h

3: toluene / 3 h / Heating

4: 60 percent / Et₃N / toluene / 4 h / Heating

5: 42 percent / H₂ / 9.81percent Pd/C / ethyl acetate; ethanol / 22 h / Ambient temperature

With thionyl chloride; hydrogen; magnesium; triethylamine; palladium on activated charcoal; In ethanol; ethyl acetate; toluene;
DOI:10.1002/ardp.19893220606

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 122504-63-6
3-4-(4-Chlorphenyl)-(4-hydroxy-3-methoxyphenyl)methyl-1-piperazinyl-methyl-benzoesaeure

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Mg / 1.) ether, 2.) reflux, 2 h

2: SOCl₂ / 1.) overnight, 2.) reflux, 1 h

3: toluene / 3 h / Heating

4: 60 percent / Et₃N / toluene / 4 h / Heating

5: 42 percent / H₂ / 9.81percent Pd/C / ethyl acetate; ethanol / 22 h / Ambient temperature

With thionyl chloride; hydrogen; magnesium; triethylamine; palladium on activated charcoal; In ethanol; ethyl acetate; toluene;
DOI:10.1002/ardp.19893220606