1',2'-dideoxy-β-1'-(3-methylphenyl)-5'-O-(4,4'-dimethoxytrityl)-D-ribofuranose

Base Information

Chemical Name:1',2'-dideoxy-β-1'-(3-methylphenyl)-5'-O-(4,4'-dimethoxytrityl)-D-ribofuranose
CAS No.:805240-85-1
Molecular Formula:C₃₃H₃₄O₅
Molecular Weight:510.63
Hs Code.:

Synonyms:1',2'-dideoxy-β-1'-(3-methylphenyl)-5'-O-(4,4'-dimethoxytrityl)-D-ribofuranose

Suppliers and Price of 1',2'-dideoxy-β-1'-(3-methylphenyl)-5'-O-(4,4'-dimethoxytrityl)-D-ribofuranose

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1',2'-dideoxy-β-1'-(3-methylphenyl)-5'-O-(4,4'-dimethoxytrityl)-D-ribofuranose

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1',2'-dideoxy-β-1'-(3-methylphenyl)-5'-O-(4,4'-dimethoxytrityl)-D-ribofuranose

There total 4 articles about 1',2'-dideoxy-β-1'-(3-methylphenyl)-5'-O-(4,4'-dimethoxytrityl)-D-ribofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 229469-60-7
1',2'-dideoxy-1'-(3-methylphenyl)-β-D-ribofuranose

: 805240-85-1
1',2'-dideoxy-β-1'-(3-methylphenyl)-5'-O-(4,4'-dimethoxytrityl)-D-ribofuranose

Guidance literature:: 1',2'-dideoxy-1'-(3-methylphenyl)-β-D-ribofuranose; With dmap; triethylamine; In pyridine; at 20 ℃; for 0.05h;

4,4'-dimethoxytrityl chloride; In pyridine; at 20 ℃; for 6h;
DOI:10.1002/chem.201200816

Reference yield:

: 173327-56-5
3,5-bis-O,O-(tert-butyldimethylsilyl)-1,2-didehydro-1,2-dideoxy-D-ribofuranose

: 805240-85-1
1',2'-dideoxy-β-1'-(3-methylphenyl)-5'-O-(4,4'-dimethoxytrityl)-D-ribofuranose

Guidance literature:: Multi-step reaction with 4 steps

1: palladium acetate; triphenylarsine; tri-n-butylamine / dimethylformamide / 16 h / 70 °C

2: tetra-n-butylammonium fluoride; AcOH / tetrahydrofuran; dimethylformamide / 1 h / 0 °C

3: 203 mg / sodium triacetoxyborohydride; AcOH / acetonitrile / 1 h

4: N,N-dimethylaminopyridine; pyridine; Et₃N / 18 h / 20 °C

With pyridine; dmap; tributyl-amine; triphenyl-arsane; tetrabutyl ammonium fluoride; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1: Heck reaction;
DOI:10.1021/ja047291m

Reference yield:

: (2R,5R)-2-Hydroxymethyl-5-m-tolyl-dihydro-furan-3-one

: 805240-85-1
1',2'-dideoxy-β-1'-(3-methylphenyl)-5'-O-(4,4'-dimethoxytrityl)-D-ribofuranose

Guidance literature:: Multi-step reaction with 2 steps

1: 203 mg / sodium triacetoxyborohydride; AcOH / acetonitrile / 1 h

2: N,N-dimethylaminopyridine; pyridine; Et₃N / 18 h / 20 °C

With pyridine; dmap; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In acetonitrile;
DOI:10.1021/ja047291m