N-(5-amino-2,4-dimethoxyphenyl)-N'-[2,4-dimethoxy-5-(2-methoxybenzoylamino)phenyl]-2-methoxyisophthalamide

Base Information

Chemical Name:N-(5-amino-2,4-dimethoxyphenyl)-N'-[2,4-dimethoxy-5-(2-methoxybenzoylamino)phenyl]-2-methoxyisophthalamide
CAS No.:774236-28-1
Molecular Formula:C₃₃H₃₄N₄O₉
Molecular Weight:630.654
Hs Code.:

Synonyms:N-(5-amino-2,4-dimethoxyphenyl)-N'-[2,4-dimethoxy-5-(2-methoxybenzoylamino)phenyl]-2-methoxyisophthalamide

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Chemical Property of N-(5-amino-2,4-dimethoxyphenyl)-N'-[2,4-dimethoxy-5-(2-methoxybenzoylamino)phenyl]-2-methoxyisophthalamide

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Technology Process of N-(5-amino-2,4-dimethoxyphenyl)-N'-[2,4-dimethoxy-5-(2-methoxybenzoylamino)phenyl]-2-methoxyisophthalamide

There total 3 articles about N-(5-amino-2,4-dimethoxyphenyl)-N'-[2,4-dimethoxy-5-(2-methoxybenzoylamino)phenyl]-2-methoxyisophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 774236-27-0
N,N'-bis(5-amino-2,4-dimethoxyphenyl)-2-methoxyisophthalamide

: 21615-34-9
2-Methoxybenzoyl chloride

: 774236-28-1
N-(5-amino-2,4-dimethoxyphenyl)-N'-[2,4-dimethoxy-5-(2-methoxybenzoylamino)phenyl]-2-methoxyisophthalamide

: N,N'-bis[2,4-dimethoxy-5-(2-methoxybenzoylamino)phenyl]-2-methoxyisophthalamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jo0490705

Reference yield:

: 1004-66-6
2-methoxy-1,3-dimethylbenzene

: 774236-28-1
N-(5-amino-2,4-dimethoxyphenyl)-N'-[2,4-dimethoxy-5-(2-methoxybenzoylamino)phenyl]-2-methoxyisophthalamide

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / KMnO₄; KOH / H₂O / 3 h / 80 °C

2: 70 percent / DCC; HOBt / tetrahydrofuran / 12 h / 20 °C

3: 20 percent / Et₃N / CH₂Cl₂ / 20 °C

With potassium hydroxide; potassium permanganate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo0490705

Reference yield:

: 1951-38-8
2-methoxyisophthalic acid

: 774236-28-1
N-(5-amino-2,4-dimethoxyphenyl)-N'-[2,4-dimethoxy-5-(2-methoxybenzoylamino)phenyl]-2-methoxyisophthalamide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / DCC; HOBt / tetrahydrofuran / 12 h / 20 °C

2: 20 percent / Et₃N / CH₂Cl₂ / 20 °C

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0490705