Technology Process of 4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorobenzaldehyde
There total 6 articles about 4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorobenzaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium carbonate; lithium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane;
for 24h;
Heating;
DOI:10.1021/jm0613323
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C
1.2: tri(isopropyl)borate / tetrahydrofuran; hexane / -78 - 20 °C
1.3: 89 percent / aq. HCl / tetrahydrofuran; hexane
2.1: 78 percent / LiCl; aq. Na2CO3 / tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane / 24 h / Heating
With
n-butyllithium; sodium carbonate; lithium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,2-dimethoxyethane; hexane;
2.1: Suzuki-Miyaura coupling;
DOI:10.1021/jm0613323
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: conc. sulfuric acid / CH2Cl2
2.1: K2CO3 / acetone / Heating
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C
3.2: tri(isopropyl)borate / tetrahydrofuran; hexane / -78 - 20 °C
3.3: 89 percent / aq. HCl / tetrahydrofuran; hexane
4.1: 78 percent / LiCl; aq. Na2CO3 / tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane / 24 h / Heating
With
n-butyllithium; sodium carbonate; potassium carbonate; lithium chloride;
tetrakis(triphenylphosphine) palladium(0); sulfuric acid;
In
tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; acetone;
1.1: Friedel-Crafts alkylation / 4.1: Suzuki-Miyaura coupling;
DOI:10.1021/jm0613323