1-(4-chlorophenyl)-4-methyl-7-(pyrazin-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

Base Information

Chemical Name:1-(4-chlorophenyl)-4-methyl-7-(pyrazin-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS No.:1084743-13-4
Molecular Formula:C₂₀H₁₉ClN₄
Molecular Weight:350.851
Hs Code.:

Synonyms:1-(4-chlorophenyl)-4-methyl-7-(pyrazin-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

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Chemical Property of 1-(4-chlorophenyl)-4-methyl-7-(pyrazin-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

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Technology Process of 1-(4-chlorophenyl)-4-methyl-7-(pyrazin-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

There total 6 articles about 1-(4-chlorophenyl)-4-methyl-7-(pyrazin-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 14508-49-7
2-chloropyrazin

: 1084744-07-9
C₂₂H₂₈BClN₂O₂

: 1084743-13-4
1-(4-chlorophenyl)-4-methyl-7-(pyrazin-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; for 2h;

Reference yield:

: 118-48-9
isatoic anhydride

: 1084743-13-4
1-(4-chlorophenyl)-4-methyl-7-(pyrazin-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 7 h / Heating / reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 7 h / 0 °C / Heating / reflux

2.2: 1 h / 20 °C

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 0 °C

4.1: caesium carbonate / palladium diacetate; XPhos / toluene / Heating / reflux

5.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 2 h / 80 °C

6.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 2 h

With pyridine; N-Bromosuccinimide; lithium aluminium tetrahydride; potassium acetate; caesium carbonate; palladium diacetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; XPhos; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1084743-67-8
C₁₀H₁₃BrN₂

: 1084743-13-4
1-(4-chlorophenyl)-4-methyl-7-(pyrazin-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / palladium diacetate; XPhos / toluene / Heating / reflux

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 2 h / 80 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 2 h

With potassium acetate; caesium carbonate; palladium diacetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; XPhos; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;