C₁₈H₂₈O₄

Base Information

• Chemical Name: C₁₈H₂₈O₄
• CAS No.: 1408299-13-7
• Molecular Formula: C₁₈H₂₈O₄
• Molecular Weight: 308.418
• Mol file: 1408299-13-7.mol

Synonyms:C₁₈H₂₈O₄

Chemical Property of C₁₈H₂₈O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₈O₄

There total 7 articles about C₁₈H₂₈O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2R,3R,6S)-7-(benzyloxy)-3-(methoxymethoxy)-2,6-dimethylheptan-1-ol (1408299-12-6) → C18H28O4 (1408299-13-7)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1016/j.tetasy.2012.07.006

Reference yield:

(S)-5-(benzyloxy)-4-methylpentan-1-ol (887706-39-0) → C18H28O4 (1408299-13-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

2.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C

2.2: 0.5 h / 0 °C

2.3: 1 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

4.1: sodium tetrahydroborate; lithium chloride / tetrahydrofuran; ethanol / 6 h / 20 °C

5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C

With sodium tetrahydroborate; di-n-butylboryl trifluoromethanesulfonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; lithium chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 2.1: |Evans Aldol Reaction / 2.2: |Evans Aldol Reaction;

DOI:10.1016/j.tetasy.2012.07.006

Reference yield:

(S)-1-((2-methylpent-4-enyloxy)methyl)benzene (391208-05-2) → C18H28O4 (1408299-13-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 0 °C

1.2: 16 h / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

3.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C

3.2: 0.5 h / 0 °C

3.3: 1 h / 0 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5.1: sodium tetrahydroborate; lithium chloride / tetrahydrofuran; ethanol / 6 h / 20 °C

6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C

With sodium tetrahydroborate; dimethylsulfide borane complex; di-n-butylboryl trifluoromethanesulfonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; lithium chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 3.1: |Evans Aldol Reaction / 3.2: |Evans Aldol Reaction;

DOI:10.1016/j.tetasy.2012.07.006

upstream raw materials:

(S)-4-benzyl-3-((S)-2-methylpent-4-enoyl)oxazolidin-2-one

(S)-5-(benzyloxy)-4-methylpentan-1-ol

benzyl bromide

(S)-1-((2-methylpent-4-enyloxy)methyl)benzene