5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-ethylene-5-methyluridine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-ethylene-5-methyluridine
• CAS No.: 287737-39-7
• Molecular Formula: C₃₃H₃₄N₂O₈
• Molecular Weight: 586.642
• Mol file: 287737-39-7.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-ethylene-5-methyluridine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-ethylene-5-methyluridine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-ethylene-5-methyluridine

There total 10 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-ethylene-5-methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 2'-O,4'-C-ethylene-5-methyluridine (287737-38-6) → 5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-ethylene-5-methyluridine (287737-39-7)

Guidance literature:

With pyridine; In dichloromethane;

DOI:10.1016/S0960-894X(01)00683-7

Reference yield:

3',5'-di-O-benzyl-2'-O,4'-C-ethylene-5-methyluridine (287737-37-5) → 5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-ethylene-5-methyluridine (287737-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / H₂ / palladium hydroxide on carbon / methanol / 5 h

2: 81 percent / pyridine / 5 h / 40 °C

With pyridine; hydrogen; palladium dihydroxide; In methanol;

DOI:10.1016/S0968-0896(03)00115-9

Reference yield:

(3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-5-(2-(tosyloxy)ethyl)tetrahydrofuran-2,3-diyl diacetate (452949-21-2) → 5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-ethylene-5-methyluridine (287737-39-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 60 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 1 h / 50 °C

2: 79 percent / NaOH; pyridine / methanol; H₂O / 0.25 h / 20 °C

3: 64 percent / H₂ / palladium hydroxide on carbon / methanol / 5 h

4: 81 percent / pyridine / 5 h / 40 °C

With pyridine; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; hydrogen; palladium dihydroxide; In methanol; water; 1,2-dichloro-ethane;

DOI:10.1016/S0968-0896(03)00115-9

upstream raw materials:

4,4'-dimethoxytrityl chloride

2'-O,4'-C-ethylene-5-methyluridine

5-Methyl-1-trimethylsilanyl-1H-pyrimidine-2,4-dione

3',5'-di-O-benzyl-2'-O,4'-C-ethylene-5-methyluridine