(S)-1-M-TOLYLETHANAMINE HCL

Base Information

• Chemical Name: (S)-1-M-TOLYLETHANAMINE HCL
• CAS No.: 1630984-18-7
• Molecular Formula: C₉H₁₃N*ClH
• Molecular Weight: 171.67
• Mol file: 1630984-18-7.mol

Synonyms:(S)-1-(m-tolyl)ethan-1-amine hydrochloride

Chemical Property of (S)-1-M-TOLYLETHANAMINE HCL

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

95-99% ^*data from raw suppliers

(S)-1-M-TolylethanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-M-TOLYLETHANAMINE HCL

There total 4 articles about (S)-1-M-TOLYLETHANAMINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C9H11N*ClH (1164111-44-7) → (S)-1-(m-tolyl)ethan-1-amine hydrochloride (1630984-18-7)

Guidance literature:

With 2,6-bis(3,5-bis(3,7-bis(trifluoromethyl)naphthalen-1-yl)phenyl)-4H-dinaphtho[2,1-d:1',2'-f][1,3,2]dithiazepine 3,3,5,5-tetraoxide; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate; In tert-butyl methyl ether; methyl cyclohexane; at 20 ℃; for 24h; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1055/s-0040-1706413

Reference yield: 66.0%

(R)-2-methyl-N-((S)-1-(m-tolyl)ethyl)propane-2-sulfinamide → (S)-1-(m-tolyl)ethan-1-amine hydrochloride (1630984-18-7)

Guidance literature:

With acetyl chloride; In ethanol; at 20 ℃; for 2h;

Reference yield:

3-Methylacetophenone (585-74-0) → (S)-1-(m-tolyl)ethan-1-amine hydrochloride (1630984-18-7)

Guidance literature:

Multi-step reaction with 3 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 60 °C

2: L-Selectride / tetrahydrofuran / -78 - 0 °C / Inert atmosphere

3: acetyl chloride / ethanol / 2 h / 20 °C

With titanium(IV) tetraethanolate; L-Selectride; acetyl chloride; In tetrahydrofuran; ethanol;

upstream raw materials:

C₉H₁₁N*ClH

3-Methylacetophenone

Downstream raw materials:

(-)-(S)-1-(3-methylphenyl)ethylamine

Refernces

• 1、 Zhao, Qingyang,Wen, Jialin,Tan, Renchang,Huang, Kexuan,Metola, Pedro,Wang, Rui,Anslyn, Eric V.,Zhang, Xumu. "Rhodium-catalyzed asymmetric hydrogenation of unprotected NH imines assisted by a thiourea". supporting information. p. 8467 - 8470. Retrieved 2014/08/18.