Technology Process of N-tert-butoxycarbonyl-5-chloro-3-phenylindole
There total 3 articles about N-tert-butoxycarbonyl-5-chloro-3-phenylindole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(2-bromo-4-chlorophenyl)-N-tert-butoxycarbonylphenylethynylamine;
With
tert.-butyl lithium;
In
diethyl ether; pentane;
at -78 ℃;
Inert atmosphere;
With
copper(I) cyanide di(lithium chloride);
In
tetrahydrofuran; diethyl ether; pentane;
at -78 - 20 ℃;
for 14h;
Inert atmosphere;
DOI:10.1021/ol4013298
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium phosphate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 24 h / Inert atmosphere; Reflux
2.1: tert.-butyl lithium / diethyl ether; pentane / -78 °C / Inert atmosphere
2.2: 14 h / -78 - 20 °C / Inert atmosphere
With
potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; tert.-butyl lithium;
In
diethyl ether; toluene; pentane;
DOI:10.1021/ol4013298
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide; silver nitrate / acetone / 20 °C / Inert atmosphere
2.1: potassium phosphate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 24 h / Inert atmosphere; Reflux
3.1: tert.-butyl lithium / diethyl ether; pentane / -78 °C / Inert atmosphere
3.2: 14 h / -78 - 20 °C / Inert atmosphere
With
potassium phosphate; N-Bromosuccinimide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; tert.-butyl lithium; silver nitrate;
In
diethyl ether; acetone; toluene; pentane;
DOI:10.1021/ol4013298
