3,6'-bis-N-benzyloxycarbonyl-1-N-(2,2,2-trichloroethoxycarbonyl)gentamicin B

Base Information

Chemical Name:3,6'-bis-N-benzyloxycarbonyl-1-N-(2,2,2-trichloroethoxycarbonyl)gentamicin B
CAS No.:73352-56-4
Molecular Formula:C₃₈H₅₁Cl₃N₄O₁₆
Molecular Weight:926.199
Hs Code.:

Synonyms:3,6'-bis-N-benzyloxycarbonyl-1-N-(2,2,2-trichloroethoxycarbonyl)gentamicin B

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Chemical Property of 3,6'-bis-N-benzyloxycarbonyl-1-N-(2,2,2-trichloroethoxycarbonyl)gentamicin B

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Technology Process of 3,6'-bis-N-benzyloxycarbonyl-1-N-(2,2,2-trichloroethoxycarbonyl)gentamicin B

There total 1 articles about 3,6'-bis-N-benzyloxycarbonyl-1-N-(2,2,2-trichloroethoxycarbonyl)gentamicin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 66065-85-8
succinimidyl 2,2,2-trichloroethyl carbonate

: 66567-23-5
3,6'-bis-N-benzyloxycarbonylgentamicin B

: 73352-56-4
3,6'-bis-N-benzyloxycarbonyl-1-N-(2,2,2-trichloroethoxycarbonyl)gentamicin B

Guidance literature:: In N,N-dimethyl-formamide; at 25 ℃; for 2h;
DOI:10.1039/P19810002186

Reference yield: 93.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 73352-56-4
3,6'-bis-N-benzyloxycarbonyl-1-N-(2,2,2-trichloroethoxycarbonyl)gentamicin B

: 73352-57-5
3,6',3''-tris-N-benzyloxycarbonyl-1-N-(2,2,2-trichloroethoxycarbonyl)gentamicin B

Guidance literature:: With sodium carbonate; In water; acetone; at 25 ℃; for 18h;
DOI:10.1039/P19810002186

Reference yield:

: 73352-56-4
3,6'-bis-N-benzyloxycarbonyl-1-N-(2,2,2-trichloroethoxycarbonyl)gentamicin B

: 79310-30-8,138382-51-1
(+/-)-1⁽³⁾-N-(4-methoxybenzyloxycarbonyl)-2-deoxystreptamine

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / sodium carbonate / acetone; H₂O / 18 h / 25 °C

2: 57 percent / acetic acid, zinc / H₂O / 48 h / 25 °C

3: 28 percent / dimethylformamide / 3 h / 25 °C

4: 49 percent / 1M-hydrochloric acid, hydrogen / 10percent palladium - carbon / H₂O; methanol / 18 h / 25 °C

5: 70 percent / methanol; H₂O / 2 h / 25 °C

With hydrogenchloride; hydrogen; sodium carbonate; acetic acid; zinc; palladium - carbon; In methanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1039/P19810002186