4-tert-butylbenzene sulfinic acid lithium salt

Base Information

• Chemical Name: 4-tert-butylbenzene sulfinic acid lithium salt
• CAS No.: 1379515-33-9
• Molecular Formula: C₁₀H₁₃O₂S*Li
• Molecular Weight: 204.219
• Mol file: 1379515-33-9.mol

Synonyms:4-tert-butylbenzene sulfinic acid lithium salt

Chemical Property of 4-tert-butylbenzene sulfinic acid lithium salt

Chemical Property:

Purity/Quality:

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Technology Process of 4-tert-butylbenzene sulfinic acid lithium salt

There total 1 articles about 4-tert-butylbenzene sulfinic acid lithium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-bromo-4-tert-butylbenzene (3972-65-4) → 4-tert-butylbenzene sulfinic acid lithium salt (1379515-33-9)

Guidance literature:

1-bromo-4-tert-butylbenzene; With n-butyllithium; phenyllithium; In tetrahydrofuran; at -80 ℃; for 0.5h;

With sulfur dioxide; In tetrahydrofuran; for 1h;

DOI:10.1016/j.bmcl.2012.01.085

Reference yield: 15.0%

4-tert-butylbenzene sulfinic acid lithium salt (1379515-33-9) + 2,3-dibromopropionic acid ethyl ester (3674-13-3) → (E)-3-(4-tert-butyl-benzenesulfonyl)acrylic acid ethyl ester (1365091-39-9)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 20h;

DOI:10.1016/j.bmcl.2012.01.085

Reference yield: 8.0%

2,3-dibromopropionamide (15102-42-8) + 4-tert-butylbenzene sulfinic acid lithium salt (1379515-33-9) → (E)-3-(4-tert-butyl-benzenesulfonyl)acrylamide (1365091-38-8)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 15h;

DOI:10.1016/j.bmcl.2012.01.085

upstream raw materials:

1-bromo-4-tert-butylbenzene

Downstream raw materials:

(E)-3-(4-tert-butyl-benzenesulfonyl)acrylamide

(E)-3-(4-tert-butyl-benzenesulfonyl)acrylic acid ethyl ester