1-methyl-(E)-2-[2-(2-thienyl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones

Base Information

Chemical Name:1-methyl-(E)-2-[2-(2-thienyl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones
CAS No.:350603-10-0
Molecular Formula:C₂₂H₂₀N₂OS
Molecular Weight:360.48
Hs Code.:

Synonyms:1-methyl-(E)-2-[2-(2-thienyl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones

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Chemical Property of 1-methyl-(E)-2-[2-(2-thienyl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones

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Technology Process of 1-methyl-(E)-2-[2-(2-thienyl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones

There total 7 articles about 1-methyl-(E)-2-[2-(2-thienyl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 350603-02-0
2-[N-methyl-N-(3'-(2-thienyl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide

: 350603-10-0
1-methyl-(E)-2-[2-(2-thienyl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones

Guidance literature:: With copper(l) iodide; tetrabutylammomium bromide; potassium carbonate; In acetonitrile; at 80 ℃; for 24h;
DOI:10.1016/S0040-4039(01)00312-4

Reference yield:

: 350602-99-2
2-(N-methyl-N-prop-2'-ynyl)amino-N'-p-tolylbenzamide

: 350603-10-0
1-methyl-(E)-2-[2-(2-thienyl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / (Ph₃P)2PdCl₂; CuI; Et₃N / acetonitrile / 16 h / 20 °C

2: 61 percent / K₂CO₃; Bu₄NBr; CuI / acetonitrile / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutylammomium bromide; potassium carbonate; triethylamine; In acetonitrile;
DOI:10.1016/S0040-4020(01)00637-8

Reference yield:

: 137105-06-7
methyl 2-(N-prop-2'-ynyl)aminobenzoate

: 350603-10-0
1-methyl-(E)-2-[2-(2-thienyl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / K₂CO₃ / dimethylformamide / 24 h / 60 °C

2: 90 percent / aq. KOH / methanol / 24 h / 20 °C

3: SOCl₂; pyridine / benzene / 1.5 h / 55 °C

4: 1.8 g / benzene / 16 h / 20 °C

5: 75 percent / (Ph₃P)2PdCl₂; CuI; Et₃N / acetonitrile / 16 h / 20 °C

6: 61 percent / K₂CO₃; Bu₄NBr; CuI / acetonitrile / 80 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; copper(l) iodide; thionyl chloride; tetrabutylammomium bromide; potassium carbonate; triethylamine; In methanol; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/S0040-4020(01)00637-8