4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylsulfonyl)methyl)-1-(methylsulfonyl)piperidine

Base Information

Chemical Name:4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylsulfonyl)methyl)-1-(methylsulfonyl)piperidine
CAS No.:1239957-24-4
Molecular Formula:C₂₆H₃₁ClFN₃O₅S₂
Molecular Weight:584.133
Hs Code.:

Synonyms:4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylsulfonyl)methyl)-1-(methylsulfonyl)piperidine

Suppliers and Price of 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylsulfonyl)methyl)-1-(methylsulfonyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylsulfonyl)methyl)-1-(methylsulfonyl)piperidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylsulfonyl)methyl)-1-(methylsulfonyl)piperidine

There total 12 articles about 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylsulfonyl)methyl)-1-(methylsulfonyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239957-23-3
4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-1-(methylsulfonyl)piperidine

: 1239957-24-4
4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylsulfonyl)methyl)-1-(methylsulfonyl)piperidine

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 5h;

Reference yield:

: 1239963-79-1
2-(4-chloro-3-methoxyphenyl)-N-methoxy-N,2-dimethylpropanamide

: 1239957-24-4
4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylsulfonyl)methyl)-1-(methylsulfonyl)piperidine

Guidance literature:: Multi-step reaction with 9 steps

1: tetrahydrofuran / 2 h / -78 - 20 °C

2: tetra-N-butylammonium tribromide / methanol; dichloromethane / 3 h / 0 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 0 - 20 °C

4: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol; water / 5 h / 2068.65 - 3361.55 Torr

5: acetic acid / 4 h / Reflux

6: potassium carbonate / acetone / 4 h / Reflux

7: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

8: triethylamine / dichloromethane / 2 h

9: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h

With hydrogenchloride; sodium azide; hydrogen; tetra-N-butylammonium tribromide; potassium carbonate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 850564-15-7
2-(4-Chloro-3-methoxy-phenyl)-2-methyl-propionitrile

: 1239957-24-4
4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylsulfonyl)methyl)-1-(methylsulfonyl)piperidine

Guidance literature:: Multi-step reaction with 11 steps

1: sulfuric acid; water / 20 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

3: tetrahydrofuran / 2 h / -78 - 20 °C

4: tetra-N-butylammonium tribromide / methanol; dichloromethane / 3 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 0 - 20 °C

6: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol; water / 5 h / 2068.65 - 3361.55 Torr

7: acetic acid / 4 h / Reflux

8: potassium carbonate / acetone / 4 h / Reflux

9: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

10: triethylamine / dichloromethane / 2 h

11: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h

With hydrogenchloride; dmap; sodium azide; sulfuric acid; water; hydrogen; tetra-N-butylammonium tribromide; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;