N-methyl-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Base Information

Chemical Name:N-methyl-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
CAS No.:1215011-22-5
Molecular Formula:C₂₂H₂₈N₆O₂S
Molecular Weight:440.569
Hs Code.:

Synonyms:N-methyl-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

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Chemical Property of N-methyl-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

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Technology Process of N-methyl-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

There total 5 articles about N-methyl-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 957198-31-1
1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-yl)piperazine

: 1215011-26-9
4-bromo-N-methyl-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide

: 1215011-22-5
N-methyl-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 120 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm500809c

Reference yield:

: potassium phosphate

: 1215011-22-5
N-methyl-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Guidance literature:: Pd(PPh₃)4; In water; oxygen; N,N-dimethyl-formamide;

Reference yield:

: 98-58-8
4-bromobenzenesulfonyl chloride

: 1215011-22-5
N-methyl-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 24 h / 20 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide / 4 h / 0 - 20 °C / Inert atmosphere

3: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 120 °C / Inert atmosphere

With pyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; In water; N,N-dimethyl-formamide; 3: |Suzuki Coupling;
DOI:10.1021/jm500809c