2-(3,5-dimethylisozaxol-4-yl)-N-(3-ethylphenyl)-4-(2-methylphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

Base Information

Chemical Name:2-(3,5-dimethylisozaxol-4-yl)-N-(3-ethylphenyl)-4-(2-methylphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
CAS No.:1095715-85-7
Molecular Formula:C₂₈H₂₉N₅O₂
Molecular Weight:467.571
Hs Code.:

Synonyms:2-(3,5-dimethylisozaxol-4-yl)-N-(3-ethylphenyl)-4-(2-methylphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

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Chemical Property of 2-(3,5-dimethylisozaxol-4-yl)-N-(3-ethylphenyl)-4-(2-methylphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

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Technology Process of 2-(3,5-dimethylisozaxol-4-yl)-N-(3-ethylphenyl)-4-(2-methylphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

There total 13 articles about 2-(3,5-dimethylisozaxol-4-yl)-N-(3-ethylphenyl)-4-(2-methylphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16114-47-9
3,5-dimethylisoxazole-4-boronic acid

: 1095717-35-3
2-chloro-N-(3-ethylphenyl)-4-(2-methylphenyl)-7,8-dihydro[4,3-d]pyrimidine-6(5H)-carboxamide

: 1095715-85-7
2-(3,5-dimethylisozaxol-4-yl)-N-(3-ethylphenyl)-4-(2-methylphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In water; N,N-dimethyl-formamide; at 90 ℃; for 16h;
DOI:10.1016/j.bmcl.2011.03.084

Reference yield:

: 98977-34-5
1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate

: 1095715-85-7
2-(3,5-dimethylisozaxol-4-yl)-N-(3-ethylphenyl)-4-(2-methylphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / methanol; water / 16 h / Reflux

2: potassium phosphate; palladium diacetate / N,N-dimethyl-formamide / 16 h / 80 °C

3: tert.-butylnitrite; antimony(III) bromide / dichloromethane / 16 h / 0 °C

4: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

5: triethylamine / dichloromethane / 2 h / 20 °C

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; N,N-dimethyl-formamide / 16 h / 90 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tert.-butylnitrite; palladium diacetate; antimony(III) bromide; sodium carbonate; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki coupling / 3: Sandmeyer reaction;
DOI:10.1016/j.bmcl.2011.03.084

Reference yield:

: 1095717-37-5
tert-butyl 2-bromo-4-(2-methylphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

: 1095715-85-7
2-(3,5-dimethylisozaxol-4-yl)-N-(3-ethylphenyl)-4-(2-methylphenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

2: triethylamine / dichloromethane / 2 h / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; N,N-dimethyl-formamide / 16 h / 90 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.03.084