3-phenyl-5-(p-tolyl)-1,2,4-thiadiazole

Base Information

• Chemical Name: 3-phenyl-5-(p-tolyl)-1,2,4-thiadiazole
• CAS No.: 50483-74-4
• Molecular Formula: C₁₅H₁₂N₂S
• Molecular Weight: 252.34
• Mol file: 50483-74-4.mol

Synonyms:3-phenyl-5-(p-tolyl)-1,2,4-thiadiazole

Chemical Property of 3-phenyl-5-(p-tolyl)-1,2,4-thiadiazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-phenyl-5-(p-tolyl)-1,2,4-thiadiazole

There total 4 articles about 3-phenyl-5-(p-tolyl)-1,2,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

benzamidine monohydrochloride (1670-14-0) + 4-Methylbenzyl bromide (104-81-4) → 3-phenyl-5-(p-tolyl)-1,2,4-thiadiazole (50483-74-4)

Guidance literature:

With sulfur; lithium tert-butoxide; In toluene; at 140 ℃; for 12h; Reagent/catalyst; Solvent; Temperature; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2017.05.061

Reference yield: 61.0%

4-tolylacetic acid (622-47-9) + benzamidine monohydrochloride (1670-14-0) → 3-phenyl-5-(p-tolyl)-1,2,4-thiadiazole (50483-74-4)

Guidance literature:

With sulfur; copper(l) iodide; sodium carbonate; In dimethyl sulfoxide; at 130 ℃; for 24h;

Reference yield: 60.0%

benzamidine monohydrochloride (1670-14-0) + 4-Methylbenzyl chloride (104-82-5) → 3-phenyl-5-(p-tolyl)-1,2,4-thiadiazole (50483-74-4)

Guidance literature:

With sulfur; sodium carbonate; In dimethyl sulfoxide; at 120 ℃; for 24h; Sealed tube;

DOI:10.1016/j.tetlet.2019.151289

upstream raw materials:

para-methylbenzonitrile

5-phenyl-1,3,4-oxathiazol-2-one

benzamidine monohydrochloride

4-Methylbenzyl bromide

Refernces

• 1、 -. "Method for synthesizing 1,2,4-thiadiazole derivative". Paragraph 0083-0088. . Retrieved 2020/05/01.
• 2、 Zhou, Zhen,Liu, Miaochang,Sun, Song,Yao, En,Liu, Suqin,Wu, Zhiwen,Yu, Jin-Tao,Jiang, Yan,Cheng, Jiang. "Multicomponent reactions (MCRs) of arylmethyl bromides, arylamidines and elemental sulfur toward unsymmetric 3,5-diaryl 1,2,4-thiadiazoles". supporting information. p. 2571 - 2573. Retrieved 2017/06/13.