tert-butyl (Z)-2-cyano-3-hydroxy-3-(4-nitrophenyl)-2-propenoate

Base Information

• Chemical Name: tert-butyl (Z)-2-cyano-3-hydroxy-3-(4-nitrophenyl)-2-propenoate
• CAS No.: 133550-24-0
• Molecular Formula: C₁₄H₁₄N₂O₅
• Molecular Weight: 290.276
• Mol file: 133550-24-0.mol

Synonyms:tert-butyl (Z)-2-cyano-3-hydroxy-3-(4-nitrophenyl)-2-propenoate

Chemical Property of tert-butyl (Z)-2-cyano-3-hydroxy-3-(4-nitrophenyl)-2-propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (Z)-2-cyano-3-hydroxy-3-(4-nitrophenyl)-2-propenoate

There total 1 articles about tert-butyl (Z)-2-cyano-3-hydroxy-3-(4-nitrophenyl)-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ tert-butyl (Z)-2-cyano-3-hydroxy-3-(4-nitrophenyl)-2-propenoate (133550-24-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h; Cooling with ice;

In tetrahydrofuran; mineral oil; at 20 ℃; for 4h;

Reference yield: 88.0%

tert-butyl (Z)-2-cyano-3-hydroxy-3-(4-nitrophenyl)-2-propenoate (133550-24-0) → (4-Nitrobenzoyl)acetonitrile (3383-43-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 3.5h; Ambient temperature;

DOI:10.1021/jm00110a022

Reference yield:

tert-butyl (Z)-2-cyano-3-hydroxy-3-(4-nitrophenyl)-2-propenoate (133550-24-0) → (E)-3-(3,4-Dihydroxy-phenyl)-2-(4-nitro-benzoyl)-acrylonitrile (133550-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / TFA / CH₂Cl₂ / 3.5 h / Ambient temperature

2: 50 percent

With trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm00110a022

Downstream raw materials:

(4-Nitrobenzoyl)acetonitrile

(E)-3-(3,4-Dihydroxy-phenyl)-2-(4-nitro-benzoyl)-acrylonitrile