2-METHYL-2-(2-METHYL-4-{([4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL][2-CHLOROBENZYL]AMINO) METHYL} PHENOXY) PROPIONIC ACID

Base Information

Chemical Name:2-METHYL-2-(2-METHYL-4-{([4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL][2-CHLOROBENZYL]AMINO) METHYL} PHENOXY) PROPIONIC ACID
CAS No.:639784-10-4
Molecular Formula:C₃₀H₂₈ClF₃N₂O₃S
Molecular Weight:589.078
Hs Code.:

Synonyms:2-METHYL-2-(2-METHYL-4-{([4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL][2-CHLOROBENZYL]AMINO) METHYL} PHENOXY) PROPIONIC ACID

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-METHYL-2-(2-METHYL-4-{([4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL][2-CHLOROBENZYL]AMINO) METHYL} PHENOXY) PROPIONIC ACID

Chemical Property:

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Technology Process of 2-METHYL-2-(2-METHYL-4-{([4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL][2-CHLOROBENZYL]AMINO) METHYL} PHENOXY) PROPIONIC ACID

There total 8 articles about 2-METHYL-2-(2-METHYL-4-{([4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL][2-CHLOROBENZYL]AMINO) METHYL} PHENOXY) PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 639784-09-1
2-Methyl-2-(2-methyl-4-{([4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-YL][2-CHLOROBENZYL]AMINO) METHYL}PHENOXY) PROPIONIC ACID ETHYL ester

: 639784-10-4
2-METHYL-2-(2-METHYL-4-{([4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL][2-CHLOROBENZYL]AMINO) METHYL} PHENOXY) PROPIONIC ACID

Guidance literature:: With sodium hydroxide; In ethanol; at 85 ℃; for 12h;

Reference yield:

: 639784-21-7
4-METHYL-2-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOL-5-YLAMINE

: 639784-10-4
2-METHYL-2-(2-METHYL-4-{([4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL][2-CHLOROBENZYL]AMINO) METHYL} PHENOXY) PROPIONIC ACID

Guidance literature:: Multi-step reaction with 4 steps

1: 2-chloro-benzaldehyde / ethanol / 12 h

2: sodium tetrahydroborate / ethanol / 0.25 h

3: ETHYL-2-METHYL-2-( (4-BROMOMETHYL-2-METHYL)PHENOXY) PROPANOATE / potassium carbonate / ethanol / 12 h / 80 °C

4: sodium hydroxide / ethanol / 12 h / 85 °C

With sodium tetrahydroborate; ETHYL-2-METHYL-2-( (4-BROMOMETHYL-2-METHYL)PHENOXY) PROPANOATE; sodium hydroxide; 2-chloro-benzaldehyde; potassium carbonate; In ethanol;

Reference yield:

: 639784-20-6
[4-METHYL-2-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOL-5-YI]-CARBAMIC acid TERT-BUTYL ester

: 639784-10-4
2-METHYL-2-(2-METHYL-4-{([4-METHYL-2-(4-TRIFLUOROMETHYLPHENYL) THIAZOL-5-YL][2-CHLOROBENZYL]AMINO) METHYL} PHENOXY) PROPIONIC ACID

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / 1 h

2: 2-chloro-benzaldehyde / ethanol / 12 h

3: sodium tetrahydroborate / ethanol / 0.25 h

4: ETHYL-2-METHYL-2-( (4-BROMOMETHYL-2-METHYL)PHENOXY) PROPANOATE / potassium carbonate / ethanol / 12 h / 80 °C

5: sodium hydroxide / ethanol / 12 h / 85 °C

With sodium tetrahydroborate; ETHYL-2-METHYL-2-( (4-BROMOMETHYL-2-METHYL)PHENOXY) PROPANOATE; sodium hydroxide; 2-chloro-benzaldehyde; trifluoroacetic acid; potassium carbonate; In ethanol;