BOC-(R)-3-AMINO-4-(3-TRIFLUOROMETHYL-PHENYL)-BUTYRIC ACID

Base Information

• Chemical Name: BOC-(R)-3-AMINO-4-(3-TRIFLUOROMETHYL-PHENYL)-BUTYRIC ACID
• CAS No.: 269726-74-1
• Molecular Formula: C₁₆H₂₀F₃NO₄
• Molecular Weight: 347.334
• Hs Code.: 2924299090
• Mol file: 269726-74-1.mol

Synonyms:N-T-Butoxycarbonyl-(R)-3-amino-4-(3-trifluoromethylphenyl)butanoic acid;N-Beta-t-butoxycarbonyl-d-homo(3-trifluoromethylphenyl)alanine;Boc-(R)-3-amino-4-(3-trifluoromethyl-phenyl)-butyric acid;

Chemical Property of BOC-(R)-3-AMINO-4-(3-TRIFLUOROMETHYL-PHENYL)-BUTYRIC ACID

Chemical Property:

• Vapor Pressure: 1.39E-08mmHg at 25°C
• Refractive Index: 1.486
• Boiling Point: 441.8 °C at 760 mmHg
• Flash Point: 221 °C
• PSA: 75.63000
• Density: 1.246 g/cm³
• LogP: 4.00680
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Boc-(R)-3-amino-4-(3-trifluoromethylphenyl)-butyric acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-(R)-3-AMINO-4-(3-TRIFLUOROMETHYL-PHENYL)-BUTYRIC ACID

There total 3 articles about BOC-(R)-3-AMINO-4-(3-TRIFLUOROMETHYL-PHENYL)-BUTYRIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[3-diazo-2-oxo-1-(3-trifluoromethyl-benzyl)-propyl]-carbamic acid tert-butyl ester → 3-tert-butoxycarbonylamino-4-(3-trifluoromethyl-phenyl)-butyric acid (269726-74-1,270065-77-5,939802-49-0)

Guidance literature:

With silver benzoate; In 1,4-dioxane; at 20 ℃; sonication;

DOI:10.1016/j.bmcl.2004.06.099

Reference yield:

((R)-2-(tert-butoxycarbonyl)amino)-3-(3-(trifluoromethyl)phenyl)propanoic acid (82317-82-6) → 3-tert-butoxycarbonylamino-4-(3-trifluoromethyl-phenyl)-butyric acid (269726-74-1,270065-77-5,939802-49-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran

2: diethyl ether

3: aq. C₆H₅CO₂Ag / dioxane / 20 °C / sonication

With silver benzoate; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether;

DOI:10.1016/j.bmcl.2004.06.099

Reference yield:

C19H24F3NO6 → 3-tert-butoxycarbonylamino-4-(3-trifluoromethyl-phenyl)-butyric acid (269726-74-1,270065-77-5,939802-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: aq. C₆H₅CO₂Ag / dioxane / 20 °C / sonication

With silver benzoate; In 1,4-dioxane; diethyl ether;

DOI:10.1016/j.bmcl.2004.06.099

upstream raw materials:

((R)-2-(tert-butoxycarbonyl)amino)-3-(3-(trifluoromethyl)phenyl)propanoic acid

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