(S)-3-(3-Hydroxy-phenyl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid

Base Information

Chemical Name:(S)-3-(3-Hydroxy-phenyl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid
CAS No.:253143-27-0
Molecular Formula:C₁₂H₁₂Cl₃NO₅
Molecular Weight:356.59
Hs Code.:

Synonyms:(S)-3-(3-Hydroxy-phenyl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid

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Chemical Property of (S)-3-(3-Hydroxy-phenyl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid

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Technology Process of (S)-3-(3-Hydroxy-phenyl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid

There total 1 articles about (S)-3-(3-Hydroxy-phenyl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 66065-85-8
succinimidyl 2,2,2-trichloroethyl carbonate

: 587-33-7,775-06-4,2180-37-2,32140-49-1,29562-33-2
m-tyrosine

: 253143-27-0
(S)-3-(3-Hydroxy-phenyl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid

Guidance literature:: With sodium hydroxide; sodium carbonate;
DOI:10.1016/S0040-4039(99)01539-7

Reference yield: 97.0%

: 253143-27-0
(S)-3-(3-Hydroxy-phenyl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid

: (S)-4-Benzyl-3-((S)-hexahydro-pyridazine-3-carbonyl)-oxazolidin-2-one; compound with trifluoro-acetic acid

: 253143-28-1
[(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-tetrahydro-pyridazin-1-yl]-1-(3-hydroxy-benzyl)-2-oxo-ethyl]-carbamic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In acetonitrile;
DOI:10.1016/S0040-4039(99)01539-7

Reference yield:

: 253143-27-0
(S)-3-(3-Hydroxy-phenyl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid

: (S)-3-{(S)-1-[(S)-2-Amino-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carbonyl}-4-benzyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / HBTU / acetonitrile

2: Zn / acetic acid

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; zinc; In acetic acid; acetonitrile; 1: Acylation / 2: Reduction;
DOI:10.1016/S0040-4039(99)01539-7