Technology Process of ent-11β-<4-(N,N-dimethylamino)-phenyl>-3,3-(2,2-dimethyl-trimethylene-1,3-dioxy)-5α-hydroxy-estr-9-en-17-one
There total 8 articles about ent-11β-<4-(N,N-dimethylamino)-phenyl>-3,3-(2,2-dimethyl-trimethylene-1,3-dioxy)-5α-hydroxy-estr-9-en-17-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 75 percent / Mg, CuCl / tetrahydrofuran / 5 deg C to r.t.
2: 70 percent / cyclohexanone, Al isopropoxide / toluene / Heating
With
cyclohexanone; aluminum isopropoxide; magnesium; copper(l) chloride;
In
tetrahydrofuran; toluene;
DOI:10.1016/S0039-128X(84)80033-1
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 96 percent / Li, liq. NH3 / tetrahydrofuran
2: 97 percent / oxalic acid / acetone / 1.5 h / Ambient temperature
3: 34 percent / pyridinium bromide perbromide / pyridine / 1.5 h / 50 °C
4: 74 percent / trimethyl orthoformate, p-toluenesulfonic acid / CH2Cl2 / Ambient temperature
5: 47 percent / H2O2, hexachloroacetone, pyridine / CH2Cl2 / 5 deg C to r.t.
6: 75 percent / Mg, CuCl / tetrahydrofuran / 5 deg C to r.t.
7: 70 percent / cyclohexanone, Al isopropoxide / toluene / Heating
With
pyridine; 1,1,1,3,3,3-hexachloro-propan-2-one; ammonia; dihydrogen peroxide; pyridinium hydrobromide perbromide; oxalic acid; cyclohexanone; aluminum isopropoxide; lithium; toluene-4-sulfonic acid; magnesium; copper(l) chloride; trimethyl orthoformate;
In
tetrahydrofuran; pyridine; dichloromethane; acetone; toluene;
DOI:10.1016/S0039-128X(84)80033-1