FMOC-L-4-PYRIDYLALANINE

Base Information

• Chemical Name: FMOC-L-4-PYRIDYLALANINE
• CAS No.: 169555-93-5
• Molecular Formula: C₈H₉FN₂O₂
• Molecular Weight: 184.17
• Hs Code.: 2933399090
• Mol file: 169555-93-5.mol

Synonyms:RARECHEM BK PT 0241;(S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PYRIDIN-4-YL-PROPIONIC ACID;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-3-(4-PYRIDYL)-L-ALANINE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-3-(4-PYRIDYL)-L-ALANINE;FMOC-4-PAL-OH;FMOC-4’-PYRIDYL-L-ALA;FMOC-ALA(4’-PYRIDYL)-OH;FMOC-ALA(4-PYRIDYL)-OH

Chemical Property of FMOC-L-4-PYRIDYLALANINE

Chemical Property:

• Boiling Point: 360.0±42.0 °C(Predicted)
• PKA: 2.03±0.10(Predicted)
• PSA: 88.52000
• Density: 1.365±0.06 g/cm3(Predicted)
• LogP: 4.00690
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-4-Pal-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-L-4-PYRIDYLALANINE

There total 2 articles about FMOC-L-4-PYRIDYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(R,S)-N-acetyl-β-(2-fluoro-5-pyridyl)alanine (169555-92-4) → (S)-β-(2-fluoro-5-pyridyl)alanine (169555-93-5,31140-74-6)

Guidance literature:

With ammonium hydroxide; hog kidney acylase; In water; at 35 ℃; for 24h;

Reference yield:

N-acetyl-2-(2-fluoro-5-pyridylmethyl)malonate (31140-65-5) → (S)-β-(2-fluoro-5-pyridyl)alanine (169555-93-5,31140-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NaOH / H₂O; ethanol / 5 h / Heating

2: 89 percent / aq. ammonia, pH 7.5, hog kidney acylase / H₂O / 24 h / 35 °C

With ammonium hydroxide; sodium hydroxide; hog kidney acylase; In ethanol; water;

Reference yield: 81.0%

(S)-β-(2-fluoro-5-pyridyl)alanine (169555-93-5,31140-74-6) → 3-aza-L-tyrosine (140681-92-1)

Guidance literature:

With hydrogenchloride; for 8h; Heating;

upstream raw materials:

(R,S)-N-acetyl-β-(2-fluoro-5-pyridyl)alanine

N-acetyl-2-(2-fluoro-5-pyridylmethyl)malonate

Downstream raw materials:

3-aza-L-tyrosine

Refernces