tert-butyl (R)-1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (R)-1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-ylcarbamate
CAS No.:936025-29-5
Molecular Formula:C₂₂H₂₄FN₃O₆
Molecular Weight:445.447
Hs Code.:

Synonyms:tert-butyl (R)-1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-ylcarbamate

Suppliers and Price of tert-butyl (R)-1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of tert-butyl (R)-1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-ylcarbamate

Chemical Property:

Purity/Quality:: 99%+, ^*data from raw suppliers

Safty Information:

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Technology Process of tert-butyl (R)-1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-ylcarbamate

There total 4 articles about tert-butyl (R)-1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 385-02-4
6-fluoro-2-nitrobenzoic acid

: 936025-29-5
tert-butyl (R)-1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride / dimethylformamide; CH₂Cl₂ / 1.5 h

2: 99 percent / NaHCO₃ / dioxane; H₂O

3: SOCl₂; DMF / 1.5 h / Heating

4: 4.88 g / NEt₃ / CH₂Cl₂ / 0 - 20 °C

With thionyl chloride; oxalyl dichloride; sodium hydrogencarbonate; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 4: Mumm rearrangement;
DOI:10.1021/ol070276c

Reference yield:

: (Z)-2-fluoro-6-nitro-N-phenylbenzimidoyl chloride

: 45121-22-0
Boc-D-Abu

: 936025-29-5
tert-butyl (R)-1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-ylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ol070276c

Reference yield:

: 870281-83-7
2-fluoro-6-nitro-N-phenyl-benzamide

: 936025-29-5
tert-butyl (R)-1-(2-fluoro-6-nitro-N-phenylbenzamido)-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂; DMF / 1.5 h / Heating

2: 4.88 g / NEt₃ / CH₂Cl₂ / 0 - 20 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; 2: Mumm rearrangement;
DOI:10.1021/ol070276c