4-[1-oxo-3-(2-furyl)-2-propenyl]-3-(3-chloro-4-fluorophenyl)sydnone

Base Information

• Chemical Name: 4-[1-oxo-3-(2-furyl)-2-propenyl]-3-(3-chloro-4-fluorophenyl)sydnone
• CAS No.: 1366133-62-1
• Molecular Formula: C₁₅H₈ClFN₂O₄
• Molecular Weight: 334.691
• Mol file: 1366133-62-1.mol

Synonyms:4-[1-oxo-3-(2-furyl)-2-propenyl]-3-(3-chloro-4-fluorophenyl)sydnone

Chemical Property of 4-[1-oxo-3-(2-furyl)-2-propenyl]-3-(3-chloro-4-fluorophenyl)sydnone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[1-oxo-3-(2-furyl)-2-propenyl]-3-(3-chloro-4-fluorophenyl)sydnone

There total 2 articles about 4-[1-oxo-3-(2-furyl)-2-propenyl]-3-(3-chloro-4-fluorophenyl)sydnone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

furfural (98-01-1) + 4-acetyl-3-(3-chloro-4-fluorophenyl)sydnone (1366133-70-1) → 4-[1-oxo-3-(2-furyl)-2-propenyl]-3-(3-chloro-4-fluorophenyl)sydnone (1366133-62-1)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 5 - 10 ℃; for 0.333333h; Sonication;

DOI:10.14233/ajchem.2015.18864

Reference yield:

3-(3-chloro-4-fluorophenyl)sydnone (68657-50-1) → 4-[1-oxo-3-(2-furyl)-2-propenyl]-3-(3-chloro-4-fluorophenyl)sydnone (1366133-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus pentoxide

2: sodium hydroxide / ethanol; water / 1 h / 5 - 10 °C

With phosphorus pentoxide; sodium hydroxide; In ethanol; water; 2: Claisen-Schmidt reaction;

DOI:10.3109/14756366.2011.586345

upstream raw materials:

furfural

4-acetyl-3-(3-chloro-4-fluorophenyl)sydnone

3-(3-chloro-4-fluorophenyl)sydnone