(αE)-α-[[5-(phenylmethoxy)-1H-indol-3-yl]methylene]-4-methoxybenzeneacetamide

Base Information

Chemical Name:(αE)-α-[[5-(phenylmethoxy)-1H-indol-3-yl]methylene]-4-methoxybenzeneacetamide
CAS No.:1450604-70-2
Molecular Formula:C₂₅H₂₂N₂O₃
Molecular Weight:398.461
Hs Code.:

Synonyms:(αE)-α-[[5-(phenylmethoxy)-1H-indol-3-yl]methylene]-4-methoxybenzeneacetamide

Suppliers and Price of (αE)-α-[[5-(phenylmethoxy)-1H-indol-3-yl]methylene]-4-methoxybenzeneacetamide

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Chemical Property of (αE)-α-[[5-(phenylmethoxy)-1H-indol-3-yl]methylene]-4-methoxybenzeneacetamide

Chemical Property:

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Technology Process of (αE)-α-[[5-(phenylmethoxy)-1H-indol-3-yl]methylene]-4-methoxybenzeneacetamide

There total 4 articles about (αE)-α-[[5-(phenylmethoxy)-1H-indol-3-yl]methylene]-4-methoxybenzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1450604-66-6
(αE)-α-[[5-(phenylmethoxy)-1H-indol-3-yl]methylene]-4-methoxybenzeneacetic acid

: 1450604-70-2
(αE)-α-[[5-(phenylmethoxy)-1H-indol-3-yl]methylene]-4-methoxybenzeneacetamide

Guidance literature:: With N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 22 ℃; for 24h;
DOI:10.1016/j.bmc.2013.06.030

Reference yield:

: 6953-22-6
5-benzyloxyindole-3-carboxaldehyde

: 1450604-70-2
(αE)-α-[[5-(phenylmethoxy)-1H-indol-3-yl]methylene]-4-methoxybenzeneacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic anhydride; triethylamine / 6 h / 130 °C

1.2: 16 h / 22 - 90 °C

2.1: sodium hydroxide / ethanol; tetrahydrofuran / 2 h / 70 °C

3.1: triethylamine; N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 0 - 22 °C

With N-hydroxybenzotriazole ammonium salt; acetic anhydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.06.030

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 1450604-70-2
(αE)-α-[[5-(phenylmethoxy)-1H-indol-3-yl]methylene]-4-methoxybenzeneacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic anhydride; triethylamine / 6 h / 130 °C

1.2: 16 h / 22 - 90 °C

2.1: sodium hydroxide / ethanol; tetrahydrofuran / 2 h / 70 °C

3.1: triethylamine; N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 0 - 22 °C

With N-hydroxybenzotriazole ammonium salt; acetic anhydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.06.030