N-(3-hydroxy-6-((2R,5R)-2-methyl-5-phenylmorpholino)pyridin-2-yl)pivalamide

Base Information

Chemical Name:N-(3-hydroxy-6-((2R,5R)-2-methyl-5-phenylmorpholino)pyridin-2-yl)pivalamide
CAS No.:1349829-81-7
Molecular Formula:C₂₁H₂₇N₃O₃
Molecular Weight:369.464
Hs Code.:

Synonyms:N-(3-hydroxy-6-((2R,5R)-2-methyl-5-phenylmorpholino)pyridin-2-yl)pivalamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-hydroxy-6-((2R,5R)-2-methyl-5-phenylmorpholino)pyridin-2-yl)pivalamide

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Technology Process of N-(3-hydroxy-6-((2R,5R)-2-methyl-5-phenylmorpholino)pyridin-2-yl)pivalamide

There total 9 articles about N-(3-hydroxy-6-((2R,5R)-2-methyl-5-phenylmorpholino)pyridin-2-yl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1349829-79-3
N-(3-formyl-6-((2R,5R)-2-methyl-5-phenylmorpholino)pyridin-2-yl)pivalamide

: 1349829-81-7
N-(3-hydroxy-6-((2R,5R)-2-methyl-5-phenylmorpholino)pyridin-2-yl)pivalamide

Guidance literature:: With urea hydrogen peroxide adduct; sodium hydroxide; In methanol; at 0 ℃; for 42h;
DOI:10.1021/op400101p

Reference yield:

: 1240349-81-8
2-chloro-N-((R)-2-hydroxy-1-phenylethyl)propionamide

: 1349829-81-7
N-(3-hydroxy-6-((2R,5R)-2-methyl-5-phenylmorpholino)pyridin-2-yl)pivalamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tert-butyl alcohol / 1 h / 20 °C

1.2: pH 4

2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 5 - 20 °C

2.2: 45 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 100 °C

4.1: sodium hydroxide; urea hydrogen peroxide adduct / methanol / 42 h / 0 °C

4.2: 0.5 h / 0 °C

With potassium tert-butylate; urea hydrogen peroxide adduct; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium hydroxide; In methanol; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 1349829-81-7
N-(3-hydroxy-6-((2R,5R)-2-methyl-5-phenylmorpholino)pyridin-2-yl)pivalamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / 2-methyltetrahydrofuran / 4 - 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / 20 °C

3: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 5 - 20 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 100 °C

5: sodium hydroxide; urea hydrogen peroxide adduct / methanol / 42 h / 0 °C

With urea hydrogen peroxide adduct; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; 5: |Dakin Phenol Oxidation;
DOI:10.1021/op400101p