ethyl 2-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)-trans-cyclopropanecarboxylate

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Chemical Name:ethyl 2-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)-trans-cyclopropanecarboxylate
CAS No.:1297551-06-4
Molecular Formula:C₂₃H₂₂ClF₄NO₃
Molecular Weight:471.879
Hs Code.:

Synonyms:ethyl 2-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)-trans-cyclopropanecarboxylate

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Chemical Property of ethyl 2-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)-trans-cyclopropanecarboxylate

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Technology Process of ethyl 2-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)-trans-cyclopropanecarboxylate

There total 5 articles about ethyl 2-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)-trans-cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1297550-14-1
(+)-(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

: rac-ethyl 2-[3-amino-4-fluorophenyl]-trans-cyclopropanecarboxylate

: 1297551-06-4
ethyl 2-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)-trans-cyclopropanecarboxylate

Guidance literature:: (+)-(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid; With pyridine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

rac-ethyl 2-[3-amino-4-fluorophenyl]-trans-cyclopropanecarboxylate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 77771-03-0
3-bromo-4-fluoro-benzyl alcohol

: 1297551-06-4
ethyl 2-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)-trans-cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: manganese(IV) oxide / toluene / Reflux

2.1: sodium hydride / dimethyl sulfoxide; paraffin oil (nujol) / 20 °C / Inert atmosphere

2.2: 50 °C

3.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 4 h / 110 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 24 h / 20 °C / 750.08 Torr

5.1: pyridine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 20 °C

With pyridine; manganese(IV) oxide; hydrogen; sodium hydride; HATU; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; paraffin oil (nujol); ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: rac-ethyl 2-(3-bromo-4-fluorophenyl)-trans-cyclopropanecarboxylate

: 1297551-06-4
ethyl 2-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluorophenyl)-trans-cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 4 h / 110 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 24 h / 20 °C / 750.08 Torr

3.1: pyridine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 20 °C

With pyridine; hydrogen; HATU; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;