(5Z)-5-{[1-(2-tert-butylbenzyl)piperidin-4-yl]methylidene}-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

Base Information

Chemical Name:(5Z)-5-{[1-(2-tert-butylbenzyl)piperidin-4-yl]methylidene}-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one
CAS No.:1422127-65-8
Molecular Formula:C₂₃H₂₉N₃OS
Molecular Weight:395.569
Hs Code.:

Synonyms:(5Z)-5-{[1-(2-tert-butylbenzyl)piperidin-4-yl]methylidene}-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

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Chemical Property of (5Z)-5-{[1-(2-tert-butylbenzyl)piperidin-4-yl]methylidene}-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

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Technology Process of (5Z)-5-{[1-(2-tert-butylbenzyl)piperidin-4-yl]methylidene}-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

There total 5 articles about (5Z)-5-{[1-(2-tert-butylbenzyl)piperidin-4-yl]methylidene}-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16358-79-5
2-tert-butylbenzaldehyde

: (5Z)-5-(piperidin-4-ylmethylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one dihydrochloride

: 1422127-65-8
(5Z)-5-{[1-(2-tert-butylbenzyl)piperidin-4-yl]methylidene}-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

Guidance literature:: 2-tert-butylbenzaldehyde; (5Z)-5-(piperidin-4-ylmethylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one dihydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1077-58-3
2-tert-butylbenzoic acid

: 1422127-65-8
(5Z)-5-{[1-(2-tert-butylbenzyl)piperidin-4-yl]methylidene}-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-THF / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

2.1: triethylamine; sulfur trioxide pyridine complex; dimethyl sulfoxide / 1 h / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 20 °C

With borane-THF; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 21190-35-2
(tert-butylphenyl)methyl alcohol

: 1422127-65-8
(5Z)-5-{[1-(2-tert-butylbenzyl)piperidin-4-yl]methylidene}-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; sulfur trioxide pyridine complex; dimethyl sulfoxide / 1 h / 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 20 °C

With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; In N,N-dimethyl-formamide;