di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]imidodicarbonate

Base Information

Chemical Name:di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]imidodicarbonate
CAS No.:784156-57-6
Molecular Formula:C₂₆H₃₈F₂N₂O₆
Molecular Weight:512.594
Hs Code.:

Synonyms:di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]imidodicarbonate

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Chemical Property of di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]imidodicarbonate

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Technology Process of di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]imidodicarbonate

There total 8 articles about di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]imidodicarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 784156-96-3
(5S)-N₂,N₂-bis(tert-butoxycarbonyl)-5-(2,3-difluorophenyl)-D-lysine

: 558-42-9
3-chloro-2-methylpropan-2-ol

: 784156-57-6
di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]imidodicarbonate

Guidance literature:: (5S)-N₂,N₂-bis(tert-butoxycarbonyl)-5-(2,3-difluorophenyl)-D-lysine; 3-chloro-2-methylpropan-2-ol; With N-ethyl-N,N-diisopropylamine; In ethanol; at 75 ℃;

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; Alkaline aqueous solution;

Reference yield:

: C₂₆H₄₀F₂N₂O₇

: 784156-57-6
di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]imidodicarbonate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 784156-57-6
di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]imidodicarbonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol; hexane; dichloromethane / 1 h / 0 °C

1.2: 24 h / 20 °C

2.1: diisobutylaluminium hydride / diethyl ether; toluene / 0.58 h / -78 - -65 °C

2.2: 0.5 h / -65 - 20 °C

3.1: N,N,N',N'-tetramethylguanidine / toluene / 0.5 h / 0 °C

3.2: 1.5 h / 0 - 20 °C

4.1: 1,4-dioxane; water / 0.25 h / Inert atmosphere

4.2: 6 h / 20 - 35 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 36 h / 2844.39 Torr

6.1: N-ethyl-N,N-diisopropylamine / ethanol / 18 h / 75 °C

6.2: 18 h / 20 °C

With hydrogen; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; N,N,N',N'-tetramethylguanidine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; toluene;