3′-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-6-benzyloxy-N²-bis-tertbutylcarbonatepurine ribonucleoside

Base Information

• Chemical Name: 3′-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-6-benzyloxy-N²-bis-tertbutylcarbonatepurine ribonucleoside
• CAS No.: 1393526-62-9
• Molecular Formula: C₃₄H₅₀FN₅O₈Si
• Molecular Weight: 703.884

Synonyms:3′-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-6-benzyloxy-N²-bis-tertbutylcarbonatepurine ribonucleoside

Chemical Property of 3′-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-6-benzyloxy-N²-bis-tertbutylcarbonatepurine ribonucleoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3′-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-6-benzyloxy-N²-bis-tertbutylcarbonatepurine ribonucleoside

There total 4 articles about 3′-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-6-benzyloxy-N²-bis-tertbutylcarbonatepurine ribonucleoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3′,5′-bis-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-6-benzyloxy-N2-bis-tertbutylcarbonatepurine ribonucleoside (1393526-54-9) → 3′-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-6-benzyloxy-N2-bis-tertbutylcarbonatepurine ribonucleoside (1393526-62-9)

Guidance literature:

With trichloroacetic acid; In tetrahydrofuran; water; at 0 - 15 ℃; for 4h;

DOI:10.1021/ol301937v

Reference yield:

3′,5′-bis-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-2-amino-6-benzyloxypurine ribonucleoside (1393526-56-1) → 3′-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-6-benzyloxy-N2-bis-tertbutylcarbonatepurine ribonucleoside (1393526-62-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / tetrahydrofuran / 3 h / 20 °C

2: trichloroacetic acid / tetrahydrofuran; water / 4 h / 0 - 15 °C

With dmap; trichloroacetic acid; In tetrahydrofuran; water;

DOI:10.1021/ol301937v

Reference yield:

(2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol → 3′-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-6-benzyloxy-N2-bis-tertbutylcarbonatepurine ribonucleoside (1393526-62-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / 1 h / 20 °C

3: dmap / tetrahydrofuran / 3 h / 20 °C

4: trichloroacetic acid / tetrahydrofuran; water / 4 h / 0 - 15 °C

With 1H-imidazole; dmap; sodium hydride; trichloroacetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1021/ol301937v

upstream raw materials:

3′,5′-bis-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-2-amino-6-chloro-purine ribonucleoside

3′,5′-bis-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-6-benzyloxy-N²-bis-tertbutylcarbonatepurine ribonucleoside

3′,5′-bis-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-2-amino-6-benzyloxypurine ribonucleoside

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1393526-62-9 3′-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-6-benzyloxy-N²-bis-tertbutylcarbonatepurine ribonucleoside

Send

Send

Metric Ton KG G Pound L ML

Send

Send